Short-term radiological results after spheroid-based autologous chondrocyte implantation in the knee are independent of defect localisation
| العنوان: | Short-term radiological results after spheroid-based autologous chondrocyte implantation in the knee are independent of defect localisation |
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| المؤلفون: | Christoph Brochhausen, Johannes Oppermann, David Grevenstein, Stavros Oikonomidis, Peer Eysel, Darius Schafigh, Christian K. Spies |
| المصدر: | Technology and Health Care. 30:725-733 |
| بيانات النشر: | IOS Press, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cartilage, Articular, Knee Joint, education, Biomedical Engineering, Biophysics, Health Informatics, Bioengineering, Articular cartilage, Osteoarthritis, Transplantation, Autologous, Biomaterials, Chondrocytes, medicine, Humans, Orthopedic Procedures, Maximum size, Autologous chondrocyte implantation, business.industry, Cartilage, Spheroid, medicine.disease, Treatment Outcome, medicine.anatomical_structure, Radiological weapon, Lateral femoral condyle, Nuclear medicine, business, Information Systems |
| الوصف: | BACKGROUND: Lesions of articular cartilage represent a crucial risk factor for the early development of osteoarthritis. Autologous chondrocyte implantation (ACI) is a well-established procedure in therapy of those lesions in the knee. The aim of the presented study is to detect differences in short-term radiological outcome depending on defect localization (femoral condyle vs. retropatellar) after spheroid-based ACI. OBJECTIVE: This study aimed to demonstrate that radiological outcome after spheroid-based ACI in the knee is independent of defect localization. METHODS: MRI-scans after retropatellar ACI and ACI of the medial/lateral femoral condyle, with a preoperative Outerbridge grade of III or IV were evaluated regarding MOCART 2.0. RESULTS: The mean defect-size was 5.0 ± 1.8 cm2, with a minimum size of 2 cm2 and a maximum size of 9 cm2. Scans were performed 7.7 months (± 3.1 months) postoperatively. The mean MOCART 2.0 score was 78.5 ± 15.6. No statistically significant influence neither of the localization (p= 0.159), the gender (p= 0.124) nor defect size (< 5 cm2 vs. ⩾ 5 cm2; p= 0.201) could be observed. CONCLUSIONS: The presented data demonstrate good to excellent radiological short-term results after spheroid-based ACI. Data indicates, that at least radiological results are independent of gender, defect-size and defect-localization. |
| تدمد: | 1878-7401 0928-7329 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dddc63bc85a2a9c17eb57ad92b0b7afbTest https://doi.org/10.3233/thc-213066Test |
| رقم الانضمام: | edsair.doi.dedup.....dddc63bc85a2a9c17eb57ad92b0b7afb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 18787401 09287329 |
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