Family History of Cancer and Risk of Biliary Tract Cancers: Results from the Biliary Tract Cancers Pooling Project
| العنوان: | Family History of Cancer and Risk of Biliary Tract Cancers: Results from the Biliary Tract Cancers Pooling Project |
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| المؤلفون: | Ruth M. Pfeiffer, Kristine R. Monroe, Susan M. Gapstur, Demetrius Albanes, Jessica L. Petrick, Xuehong Zhang, Roger L. Milne, Jill Koshiol, Linda M. Liao, Rashmi Sinha, Katherine A. McGlynn, Francine Grodstein, Peter T. Campbell, Kim Robien, Mark P. Purdue, Alison L. Van Dyke, Stephanie J. Weinstein, Jenny N. Poynter, Juhua Luo, Catherine Schairer, Marian L. Neuhouser, Laura E. Beane Freeman, Neal D. Freedman, Andrew T. Chan, Bin Zhu, Margaret S Langhamer, Gabriella Andreotti, Graham G. Giles |
| المصدر: | Cancer Epidemiology, Biomarkers & Prevention. 27:348-351 |
| بيانات النشر: | American Association for Cancer Research (AACR), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Epidemiology, medicine.medical_treatment, Gastroenterology, Article, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, medicine, Humans, Prospective Studies, cardiovascular diseases, Gastrointestinal cancer, Gallbladder cancer, Medical History Taking, Aged, Biliary tract neoplasm, business.industry, Incidence, Gallbladder, Ampulla of Vater, Cancer, Middle Aged, medicine.disease, Biliary Tract Neoplasms, medicine.anatomical_structure, Oncology, Biliary tract, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Cholecystectomy, business, Follow-Up Studies |
| الوصف: | Background: Although some familial cancer syndromes include biliary tract cancers (BTCs; cancers of the gallbladder, intrahepatic and extrahepatic bile ducts, and ampulla of Vater), the few studies that have examined the relationships between family history of cancer (FHC) and BTCs have reported inconclusive findings. The objective of this study was to investigate the associations of FHC with risk of BTC in the Biliary Tract Cancers Pooling Project (BiTCaPP). Methods: We used Cox proportional hazards regressions models to estimate HRs and 95% confidence intervals for associations between FHC (any, first-degree, in female relative, in male relative, relative with gastrointestinal cancer, and relative with hormonally related cancer) and BTC risk by anatomic site within the biliary tract, adjusting for sex and race/ethnicity. Sensitivity analyses were conducted that restricted to studies reporting cholecystectomy data and to people without a history of cholecystectomy. Results: Data on FHC were available from 12 prospective studies within BiTCaPP, which collectively contributed 2,246 cases (729 gallbladder, 345 intrahepatic and 615 extrahepatic bile duct, and 385 ampulla of Vater cancers) with 21,706,107 person-years of follow-up. A marginal, inverse association between FHC and gallbladder cancer was driven to the null when analysis was restricted to studies reporting cholecystectomy data and to people without a history of cholecystectomy. FHC was not associated with risk of BTC at the other anatomic sites. Conclusions: These findings do not support an association between FHC and BTCs. Impact: In a study of 1.5 million people, FHC is not a risk factor for BTCs. Cancer Epidemiol Biomarkers Prev; 27(3); 348–51. ©2018 AACR. |
| تدمد: | 1538-7755 1055-9965 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd94f3582a33424fff4eb0d998eb7760Test https://doi.org/10.1158/1055-9965.epi-17-1003Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dd94f3582a33424fff4eb0d998eb7760 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15387755 10559965 |
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