التفاصيل البيبلوغرافية
العنوان:
High pretherapeutic thymidylate synthetase and MRP-1 protein levels are associated with nonresponse to neoadjuvant chemotherapy in oesophageal adenocarcinoma patients
المؤلفون:
Heinz Höfler , Karen Becker , Marcus Feith , Rupert Langer , Florian Lordick , Katja Specht , Katja Ott
المصدر:
Journal of Surgical Oncology . 102:503-508
بيانات النشر:
Wiley, 2010.
سنة النشر:
2010
مصطلحات موضوعية:
Adult , Male , Oncology , medicine.medical_specialty , Esophageal Neoplasms , medicine.medical_treatment , Antineoplastic Agents , Adenocarcinoma , Thymidylate synthase , Internal medicine , medicine , Humans , ATP Binding Cassette Transporter, Subfamily B, Member 1 , Survival analysis , Aged , Cisplatin , Messenger RNA , Chemotherapy , biology , business.industry , Thymidylate Synthase , General Medicine , Middle Aged , Endonucleases , Survival Analysis , Neoadjuvant Therapy , Neoplasm Proteins , DNA-Binding Proteins , Treatment Outcome , Chemotherapy, Adjuvant , Fluorouracil , biology.protein , Immunohistochemistry , Female , Surgery , ERCC1 , business , medicine.drug
الوصف:
Background The aim of this study was to determine whether pretherapeutic protein expression levels of the excision repair cross-complementing (ERCC1) enzyme, thymidylate synthetase (TS), multidrug-resistance protein 1 (MRP-1) and P-glycoprotein (P-gp) are associated with tumour response to cisplatin and fluorouracil (5-FU)-based neoadjuvant chemotherapy in oesophageal adenocarcinomas Methods The expression levels of ERCC1, TS, MDR-1 and P-gp were determined immunohistochemically in pretherapeutic tumour biopsies from 40 oesophageal adenocarcinoma patients and were correlated with histopathological tumour regression and with patient survival. Protein expression was compared to mRNA data, which was previously published for ERCC1, TS and MRP-1 and newly determined for the purpose of this study for MDR-1/P-gp. Results High-TS and -MRP-1 protein expression was correlated with tumour non-response to chemotherapy (P = 0.001 and P = 0.036, respectively). For ERCC-1 and P-gp, no association between pretherapeutic protein expression and response was found. There was no correlation between mRNA levels and protein expression for all investigated markers. Survival analysis revealed a trend towards increased survival for low-ERCC-1 expression (P = 0.079). Conclusions The pattern of pretherapeutic expression of TS and MRP-1 is related to chemotherapy response in oesophageal adenocarcinoma patients. Immunohistochemical assessment of these markers may be helpful for response prediction. J. Surg. Oncol. 2010;102:503–508. © 2010 Wiley-Liss, Inc.
تدمد:
0022-4790
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcdd3728fecc5f2cb02d164f1ddb42fdTest https://doi.org/10.1002/jso.21641Test
حقوق:
CLOSED
رقم الانضمام:
edsair.doi.dedup.....dcdd3728fecc5f2cb02d164f1ddb42fd
قاعدة البيانات:
OpenAIRE
