Calsyntenin 1-mediated trafficking of axon guidance receptors regulates the switch in axonal responsiveness at a choice point
| العنوان: | Calsyntenin 1-mediated trafficking of axon guidance receptors regulates the switch in axonal responsiveness at a choice point |
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| المؤلفون: | Tobias Alther, Esther T. Stoeckli, Elena Domanitskaya |
| المساهمون: | University of Zurich, Stoeckli, Esther T |
| المصدر: | Development |
| بيانات النشر: | The Company of Biologists, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Frizzled, Growth Cones, Receptors, Cell Surface, Biology, Avian Proteins, 1309 Developmental Biology, 03 medical and health sciences, 0302 clinical medicine, ROBO1, Chlorocebus aethiops, medicine, 1312 Molecular Biology, Calsyntenin, Animals, Gene Silencing, Axon, Growth cone, Molecular Biology, Floor plate, Guanine Nucleotide Dissociation Inhibitors, 030304 developmental biology, 0303 health sciences, Calcium-Binding Proteins, Wnt signaling pathway, Anatomy, Cell Biology, Axons, 10124 Institute of Molecular Life Sciences, Protein Transport, 030104 developmental biology, medicine.anatomical_structure, Phenotype, COS Cells, 570 Life sciences, biology, Axon guidance, Neuroscience, Chickens, 030217 neurology & neurosurgery, Developmental Biology |
| الوصف: | Axon guidance at choice points depends on the precise regulation of guidance receptors on the growth cone surface. Upon arrival at the intermediate target or choice point, a switch from attraction to repulsion is required for the axon to move on. Dorsal commissural (dI1) axons crossing the ventral midline of the spinal cord in the floor plate represent a convenient model for the analysis of the molecular mechanism underlying the switch in axonal behavior. We identified a role of Calsyntenin1 in the regulation of vesicular trafficking of guidance receptors in dI1 axons at choice points. In cooperation with RabGDI, Calsyntenin1 shuttles Rab11-positive vesicles containing Robo1 to the growth cone surface in a precisely regulated manner. In contrast, Calsyntenin1-mediated trafficking of Frizzled3, a guidance receptor in the Wnt pathway, is independent of RabGDI. Thus, tightly regulated insertion of guidance receptors, which is required for midline crossing and the subsequent turn into the longitudinal axis, is achieved by specific trafficking. |
| وصف الملف: | 528.pdf - application/pdf |
| تدمد: | 1477-9137 0021-9533 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca5fde0bb139c632247e38cb4b4bef6Test https://doi.org/10.1242/jcs.189274Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dca5fde0bb139c632247e38cb4b4bef6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14779137 00219533 |
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