Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques
| العنوان: | Clinical features of irreversible rejection after allogeneic uterus transplantation in cynomolgus macaques |
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| المؤلفون: | Hideaki Tsuchiya, Daisuke Aoki, Hideaki Obara, Yusuke Matoba, Masatsugu Ema, Takashi Shiina, Takahiro Nakagawa, Hirohito Ishigaki, Kouji Banno, Mitsuru Murase, Yohei Yamada, Iori Itagaki, Hiroyuki Urano, Ikuo Kawamoto, Iori Kisu, Yoko Saiki, Kentaro Matsubara, Kenshi Nakagawa, Yohei Masugi, Chizuru Iwatani, Katsura Emoto, Kazumasa Ogasawara, Yojiro Kato |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-9 (2020) |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Graft Rejection, Indocyanine Green, medicine.medical_specialty, Pathology, Time Factors, Reproductive disorders, medicine.medical_treatment, Uterus, lcsh:Medicine, Article, 03 medical and health sciences, chemistry.chemical_compound, Leukocyte Count, 0302 clinical medicine, Laparotomy, Internal medicine, Uterus transplantation, medicine, Animals, Transplantation, Homologous, lcsh:Science, Ultrasonography, Immunosuppression Therapy, Multidisciplinary, Hysterectomy, Hematology, L-Lactate Dehydrogenase, business.industry, lcsh:R, Optical Imaging, Immunosuppression, Transplantation, Experimental models of disease, Macaca fascicularis, 030104 developmental biology, medicine.anatomical_structure, C-Reactive Protein, chemistry, Infertility, lcsh:Q, Female, business, Indocyanine green, 030217 neurology & neurosurgery |
| الوصف: | Uterus transplantation (UTx) is a potential option for women with uterine factor infertility to have a child. The clinical features indicating irreversible rejection of the uterus are unknown. In our experimental series of allogeneic UTx in cynomolgus macaques, six female macaques were retrospectively examined, which were unresponsive to treatment with immunosuppressants (i.e. irreversible rejection). Clinical features including general condition, hematology, uterine size, indocyanine green (ICG) fluorescence imaging by laparotomy, and histopathological findings of the removed uterus were evaluated. In all cases, general condition was good at the time of diagnosis of irreversible rejection and thereafter. Laboratory evaluation showed temporary increases in white blood cells, lactate dehydrogenase and C-reactive protein, then these levels tended to decrease gradually. In transabdominal ultrasonography, the uterus showed time-dependent shrinkage after transient swelling at the time of diagnosis of irreversible rejection. In laparotomy, a whitish transplanted uterus was observed and enhancement of the transplanted uterus was absent in ICG fluorescence imaging. Histopathological findings in each removed uterus showed hyalinized fibrosis, endometrial deficit, lymphocytic infiltration and vasculitis. These findings suggest that uterine transplantation rejection is not fatal, in contrast to rejection of life-supporting organs. Since the transplanted uterus with irreversible rejection atrophies naturally, hysterectomy may be unnecessary. |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc8e91f1b6eb3d79276608c6a9122135Test https://pubmed.ncbi.nlm.nih.gov/32807830Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dc8e91f1b6eb3d79276608c6a9122135 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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