High-density lipoprotein subspecies between patients with type 1 diabetes and type 2 diabetes without / with intensive insulin therapy
العنوان: | High-density lipoprotein subspecies between patients with type 1 diabetes and type 2 diabetes without / with intensive insulin therapy |
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المؤلفون: | Tsutomu Hirano, Tomoyasu Fukui |
المصدر: | Endocrine Journal. 59:561-569 |
بيانات النشر: | Japan Endocrine Society, 2012. |
سنة النشر: | 2012 |
مصطلحات موضوعية: | Adult, Male, endocrine system, medicine.medical_specialty, endocrine system diseases, Apolipoprotein B, Diet therapy, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Administration, Oral, Type 2 diabetes, chemistry.chemical_compound, Endocrinology, High-density lipoprotein, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, Aged, Type 1 diabetes, Dose-Response Relationship, Drug, biology, nutritional and metabolic diseases, Middle Aged, medicine.disease, Combined Modality Therapy, Exercise Therapy, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, chemistry, Case-Control Studies, biology.protein, Drug Therapy, Combination, Female, lipids (amino acids, peptides, and proteins), Lipoproteins, HDL, Diet Therapy, Lipoprotein |
الوصف: | The reduced levels of high-density lipoprotein (HDL) 2-cholesterol (C) in diabetes and other metabolic disorders associated with a high risk of cardiovascular disease are well established. Few studies, however, have compared the HDL subspecies in type 1 diabetes (T1D) with those in type 2 diabetes (T2D) with or without insulin. We examined HDL subspecies in 27 T1D with insulin, 33 T2D with insulin or insulin plus oral-anti-diabetic drugs (OADs), 36 T2D with OADs or diet/exercise, and 25 non-diabetic controls. Insulin was injected four times daily in a basal-bolus manner for both T1D and T2D. Plasma levels of C, apolipoprotein (apo) AI, and AII were determined in HDL2 and HDL3 by the single precipitation method. HDL-C levels were significantly higher in T1D and lower in T2D, compared with the controls. Insulin-treated T2D had higher HDL-C than non-insulin-treated T2D. T1D had higher HDL2-C and HDL2-apo AI levels than T2D. Insulin-treated T2D had higher HDL2-C and HDL2-apo AI levels than non-insulin-treated T2D. All of these differences were more pronounced for men than for women. HDL3 levels were comparable among controls,T1D and T2D. HDL2-C levels were inversely associated with BMI, HbA1c, triglyceride, small dense LDL-C, and LDL-C. Multiple regression analysis revealed that HDL2-C was independently associated with triglyceride, LDL-C, and intensive insulin therapy but not with HbA1c. In conclusion, these results suggest that intensive insulin therapy is associated with alterations of HDL subspecies, irrespective of the type of diabetes. |
تدمد: | 1348-4540 0918-8959 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc05c9aa4c697e6ac3d62d2c55c1ce78Test https://doi.org/10.1507/endocrj.ej11-0329Test |
حقوق: | OPEN |
رقم الانضمام: | edsair.doi.dedup.....dc05c9aa4c697e6ac3d62d2c55c1ce78 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 13484540 09188959 |
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