Selenium and viral infection: are there lessons for COVID-19?
| العنوان: | Selenium and viral infection: are there lessons for COVID-19? |
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| المؤلفون: | Giovanna Bermano, Derry K. Mercer, Catherine Méplan, John E. Hesketh |
| المصدر: | The British Journal of Nutrition British Journal of Nutrition |
| بيانات النشر: | Cambridge University Press, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Medicine (miscellaneous), GPX, glutathione peroxidase, Nrf2, nuclear factor erythroid 2-related factor 2, CVB, coxsackievirus B3, UPR, unfolded protein response, Interferon, Epidemiology, Severe acute respiratory syndrome coronavirus 2, Micronutrients, TXNRD, thioredoxin reductase, Letter to the Editor, COVID-19, coronavirus disease 2019, education.field_of_study, Nutrition and Dietetics, Selenoprotein S, NF-κB, nuclear factor kappa-light-chain-enhancer of activated B cells, Micronutrient, NOX, NADPH oxidase, SELENOS, selenoprotein S, Redox status, Virus Diseases, SELENOF, selenoprotein F, RNA, Viral, IV, influenza virus, Animal studies, medicine.symptom, Oxidation-Reduction, Systematic Review and Meta-Analysis, medicine.drug, medicine.medical_specialty, Population, Nutritional Status, Inflammation, Biology, SARS-CoV-2, severe acute respiratory syndrome coronavirus 2, ER, endoplasmic reticulum, 03 medical and health sciences, Selenium, ROS, reactive oxygen species, Stress, Physiological, medicine, Animals, Humans, IFN, interferon, education, 030109 nutrition & dietetics, SARS-CoV-2, MERS, Middle East respiratory syndrome, COVID-19, medicine.disease, 030104 developmental biology, Viral infection, Immunology, Middle East respiratory syndrome, biology.gene |
| الوصف: | Se is a micronutrient essential for human health. Sub-optimal Se status is common, occurring in a significant proportion of the population across the world including parts of Europe and China. Human and animal studies have shown that Se status is a key determinant of the host response to viral infections. In this review, we address the question whether Se intake is a factor in determining the severity of response to coronavirus disease 2019 (COVID-19). Emphasis is placed on epidemiological and animal studies which suggest that Se affects host response to RNA viruses and on the molecular mechanisms by which Se and selenoproteins modulate the inter-linked redox homeostasis, stress response and inflammatory response. Together these studies indicate that Se status is an important factor in determining the host response to viral infections. Therefore, we conclude that Se status is likely to influence human response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and that Se status is one (of several) risk factors which may impact on the outcome of SARS-CoV-2 infection, particularly in populations where Se intake is sub-optimal or low. We suggest the use of appropriate markers to assess the Se status of COVID-19 patients and possible supplementation may be beneficial in limiting the severity of symptoms, especially in countries where Se status is regarded as sub-optimal. |
| اللغة: | English |
| تدمد: | 1475-2662 0007-1145 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbaf9f791d4be7223448b47e450803a1Test http://europepmc.org/articles/PMC7503044Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dbaf9f791d4be7223448b47e450803a1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14752662 00071145 |
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