NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions
| العنوان: | NK Cell Responses in Zika Virus Infection Are Biased towards Cytokine-Mediated Effector Functions |
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| المؤلفون: | Hans Yssel, Aurélien Corneau, Luana Leandro Gois, Christopher Maucourant, Catherine Blanc, Maria Fernanda Rios Grassi, Nadine Tarantino, Aïda Meghraoui-Kheddar, Vincent Vieillard, Assia Samri, Antonio Bandeira, Gabriel Andrade Nonato Queiroz |
| المساهمون: | Centre d'Immunologie et de Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Cytométrie Pitié-Salpêtrière (PASS-CYPS), Unité Mixte de Service Production et Analyse de données en Sciences de la vie et en Santé (PASS), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM), Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| المصدر: | Journal of Immunology Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2021, 207 (5), pp.1333-1343. ⟨10.4049/jimmunol.2001180⟩ |
| بيانات النشر: | HAL CCSD, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | medicine.medical_treatment, [SDV]Life Sciences [q-bio], Immunology, Cell, Lymphocyte Activation, Zika virus, Cohort Studies, Interferon-gamma, 03 medical and health sciences, 0302 clinical medicine, Immune system, Pregnancy, MHC class I, STAT5 Transcription Factor, medicine, Humans, Immunology and Allergy, Mass cytometry, Cells, Cultured, ComputingMilieux_MISCELLANEOUS, 030304 developmental biology, 0303 health sciences, biology, Tumor Necrosis Factor-alpha, Zika Virus Infection, Receptors, KIR3DL1, Zika Virus, biology.organism_classification, Interleukin-12, 3. Good health, Killer Cells, Natural, Flavivirus, Cytokine, medicine.anatomical_structure, Acute Disease, biology.protein, Female, KIR3DL1, 030215 immunology |
| الوصف: | Zika virus (ZIKV) is a mosquito-borne flavivirus that has emerged as a global concern because of its impact on human health. ZIKV infection during pregnancy can cause microcephaly and other severe brain defects in the developing fetus and there have been reports of the occurrence of Guillain-Barré syndrome in areas affected by ZIKV. NK cells are activated during acute viral infections and their activity contributes to a first line of defense because of their ability to rapidly recognize and kill virus-infected cells. To provide insight into NK cell function during ZIKV infection, we have profiled, using mass cytometry, the NK cell receptor-ligand repertoire in a cohort of acute ZIKV-infected female patients. Freshly isolated NK cells from these patients contained distinct, activated, and terminally differentiated, subsets expressing higher levels of CD57, NKG2C, and KIR3DL1 as compared with those from healthy donors. Moreover, KIR3DL1+ NK cells from these patients produced high levels of IFN-γ and TNF-α, in the absence of direct cytotoxicity, in response to in vitro stimulation with autologous, ZIKV-infected, monocyte-derived dendritic cells. In ZIKV-infected patients, overproduction of IFN-γ correlated with STAT-5 activation (r = 0.6643; p = 0.0085) and was mediated following the recognition of MHC class 1–related chain A and chain B molecules expressed by ZIKV-infected monocyte-derived dendritic cells, in synergy with IL-12 production by the latter cells. Together, these findings suggest that NK cells contribute to the generation of an efficacious adaptive anti-ZIKV immune response that could potentially affect the outcome of the disease and/or the development of persistent symptoms. |
| اللغة: | English |
| تدمد: | 0022-1767 1550-6606 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5d75fe68fe719df4371b6278b29f3bTest https://hal.archives-ouvertes.fr/hal-03382710Test |
| رقم الانضمام: | edsair.doi.dedup.....db5d75fe68fe719df4371b6278b29f3b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00221767 15506606 |
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