Characterizing dedifferentiation of thyroid cancer by integrated analysis
| العنوان: | Characterizing dedifferentiation of thyroid cancer by integrated analysis |
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| المؤلفون: | Zhinan Xue, Tao Wei, Han Luo, Huairong Tang, Wei Cheng, Yong Jiang, Jihwan Park, Xuyang Xia, Lingyun Zhang, Yan Chen, Yang Liu, Carlos Caulin, Hongbo Hu, Birong Dong, Zhihui Li, Yang Shu, Jingqiang Zhu, Gong Changyang, Ruicen Li, Tian Yang, Heng Xu, Hai-Ning Chen, Shouyue Zhang, Gyeong Dae Kim, Wei-Han Zhang, Lunzhi Dai, Yong Peng, Wei Zhang, Xianghui Fu, Li Yang, Yiguo Hu |
| المصدر: | Science Advances |
| بيانات النشر: | American Association for the Advancement of Science (AAAS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Multidisciplinary, endocrine system diseases, SciAdv r-articles, RNA, Human Genetics, Biology, medicine.disease, Papillary thyroid cancer, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, Developmental trajectory, Copy Number Alteration, Molecular evolution, 030220 oncology & carcinogenesis, Cancer research, medicine, Anaplastic thyroid cancer, Gene, Thyroid cancer, Research Articles, Research Article, Cancer |
| الوصف: | Clinical staining and targeting CREB3L1 facilitates precise stratification and a potential treatment strategy for thyroid cancer. Understanding of dedifferentiation, an indicator of poo prognosis for patients with thyroid cancer, has been hampered by imprecise and incomplete characterization of its heterogeneity and its attributes. Using single-cell RNA sequencing, we explored the landscape of thyroid cancer at single-cell resolution with 46,205 cells and delineated its dedifferentiation process and suppressive immune microenvironment. The developmental trajectory indicated that anaplastic thyroid cancer (ATC) cells were derived from a small subset of papillary thyroid cancer (PTC) cells. Moreover, a potential functional role of CREB3L1 on ATC development was revealed by integrated analyses of copy number alteration and transcriptional regulatory network. Multiple genes in differentiation-related pathways (e.g., EMT) were involved as the downstream targets of CREB3L1, increased expression of which can thus predict higher relapse risk of PTC. Collectively, our study provided insights into the heterogeneity and molecular evolution of thyroid cancer and highlighted the potential driver role of CREB3L1 in its dedifferentiation process. |
| تدمد: | 2375-2548 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db371a447f6e1784842d8b8c608a6dbbTest https://doi.org/10.1126/sciadv.abf3657Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....db371a447f6e1784842d8b8c608a6dbb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 23752548 |
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