Breast cancer risk and 6q22.33: Combined results from breast cancer association consortium and consortium of investigators on modifiers of brca1/2
| العنوان: | Breast cancer risk and 6q22.33: Combined results from breast cancer association consortium and consortium of investigators on modifiers of brca1/2 |
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| المؤلفون: | Kirchhoff, T., Gaudet, M.M., Antoniou, A.C., McGuffog, L., Humphreys, M.K., Dunning, A.M., Bojesen, S.E., Nordestgaard, B.G., Flyger, H., Kang, D., Yoo, K.Y., Noh, D.Y., Ahn, S.H., Dork, T., Schurmann, P., Karstens, J.H., Hillemanns, P., Couch, F.J., Olson, J., Vachon, C., Wang, X.S., Cox, A., Brock, I., Elliott, G., Reed, M.W.R., Burwinkel, B., Meindl, A., Brauch, H., Hamann, U., Ko, Y.D., Broeks, A., Schmidt, M.K., Veer, L.J. van 't, Braaf, L.M., Johnson, N., Fletcher, O., Gibson, L., Peto, J., Turnbull, C., Seal, S., Renwick, A., Rahman, N., Wu, P.E., Yu, J.C., Hsiung, C.N., Shen, C.Y., Southey, M.C., Hopper, J.L., Hammet, F., Dorpe, T. van, Dieudonne, A.S., Hatse, S., Lambrechts, D., Andrulis, I.L., Bogdanova, N., Antonenkova, N., Rogov, J.I., Prokofieva, D., Bermisheva, M., Khusnutdinova, E., Asperen, C.J. van, Tollenaar, R.A.E.M., Hooning, M.J., Devilee, P., Margolin, S., Lindblom, A., Milne, R.L., Arias, J.I., Zamora, M.P., Benitez, J., Severi, G., Baglietto, L., Giles, G.G., Spurdle, A.B., Beesley, J., Chen, X.Q., Holland, H., Healey, S., Wang-Gohrke, S., Chang-Claude, J., Mannermaa, A., Kosma, V.M., Kauppinen, J., Kataja, V., Agnarsson, B.A., Caligo, M.A., Godwin, A.K., Nevanlinna, H., Heikkinen, T., Fredericksen, Z., Lindor, N., Nathanson, K.L., Domchek, S.M., Loman, N., Karlsson, P., Askmalm, M.S., Melin, B., Wachenfeldt, A. von, Hogervorst, F.B.L., Verheus, M., Rookus, M.A., Seynaeve, C., Oldenburg, R.A., Ligtenberg, M.J., Ausems, M.G.E.M., Aalfs, C.M., Gille, H.J.P., Wijnen, J.T., Garcia, E.B.G., Peock, S., Cook, M., Oliver, C.T., Frost, D., Luccarini, C., Pichert, G., Davidson, R., Chu, C., Eccles, D., Ong, K.R., Cook, J., Douglas, F., Hodgson, S., Evans, D.G., Eeles, R., Gold, B., Pharoah, P.D.P., Offit, K., Chenevix-Trench, G., Easton, D.F., GENICA Network, kConFab, AOCS Study Grp, SWE-BRCA, HEBON, EMBRACE, BCAC-CIMBA |
| المساهمون: | Medical Oncology, Clinical Genetics, Genetica & Celbiologie, RS: GROW - School for Oncology and Reproduction, Human genetics, CCA - Oncogenesis, Department of Obstetrics and Gynecology, Women's Health Research Program, Human Genetics, Cancer Center Amsterdam, Amsterdam Reproduction & Development (AR&D) |
| المصدر: | PLoS One (print), 7(6). Public Library of Science PLOS ONE, 7(6):e35706. Public Library of Science PLoS ONE, 7(6):e35706. Public Library of Science Kirchhoff, T, Gaudet, M M, Antoniou, A C, McGuffog, L, Humphreys, M K, Dunning, A M, Bojesen, S E, Nordestgaard, B G, Flyger, H, Kang, D, Yoo, K Y, Noh, D Y, Ahn, S H, Dork, T, Schurmann, P, Karstens, J H, Hillemanns, P, Couch, F J, Olson, J, Vachon, C, Wang, X S, Cox, A, Brock, I, Elliott, G, Reed, M W R, Burwinkel, B, Meindl, A, Brauch, H, Hamann, U, Ko, Y D, Broeks, A, Schmidt, M K, van 't Veer, L J, Braaf, L M, Johnson, N, Fletcher, O, Gibson, L, Peto, J, Turnbull, C, Seal, S, Renwick, A, Rahman, N, Wu, P E, Yu, J C, Hsiung, C N, Shen, C Y, Southey, M C, Hopper, J L, Hammet, F, Van Dorpe, T, Dieudonne, A S, Hatse, S, Lambrechts, D, Andrulis, I L, Bogdanova, N, Antonenkova, N, Rogov, J I, Prokofieva, D, Bermisheva, M, Khusnutdinova, E, van Asperen, C J, Tollenaar, R A E M, Hooning, M J, Devilee, P, Margolin, S, Lindblom, A, Milne, R L, Arias, J I, Zamora, M P, Benitez, J, Severi, G, Baglietto, L, Giles, G G, Spurdle, A B, Beesley, J, Chen, X Q, Holland, H, Healey, S, Wang-Gohrke, S, Chang-Claude, J, Mannermaa, A, Kosma, V M, Kauppinen, J, Kataja, V, Agnarsson, B A, Caligo, M A, Godwin, A K, Nevanlinna, H, Heikkinen, T, Fredericksen, Z, Lindor, N, Nathanson, K L, Domchek, S M, Loman, N, Karlsson, P, Askmalm, M S, Melin, B, von Wachenfeldt, A, Hogervorst, F B L, Gille, J J P, Chenevix-Trench, G & Easton, D F 2012, ' Breast Cancer Risk and 6q22.33: Combined Results from Breast Cancer Association Consortium and Consortium of Investigators on Modifiers of BRCA1/2 ', PLoS ONE, vol. 7, no. 6, e35706 . https://doi.org/10.1371/journal.pone.0035706Test PLoS One, 7, 6 PLoS One, 7 PLoS ONE, Vol 7, Iss 6, p e35706 (2012) PLoS ONE PLoS ONE, 7(6). Public Library of Science PLoS ONE, 7(6) PLoS ONE; 7(6) (2012) |
| سنة النشر: | 2012 |
| مصطلحات موضوعية: | Oncology, Genetics and Molecular Biology (all), Medicin och hälsovetenskap, Alleles, BRCA1 Protein, BRCA2 Protein, Breast Neoplasms, Chromosomes, Human, Pair 6, Confidence Intervals, Female, Genetic Association Studies, Heterozygote, Humans, Middle Aged, Odds Ratio, Polymorphism, Single Nucleotide, Proportional Hazards Models, Receptors, Estrogen, Risk Factors, Genetic Predisposition to Disease, Medicine (all), Biochemistry, Genetics and Molecular Biology (all), Agricultural and Biological Sciences (all), Epidemiology, Genome-wide association study, VARIANTS, Bioinformatics, Medical and Health Sciences, Biochemistry, 0302 clinical medicine, Breast Tumors, Genotype, Receptors, skin and connective tissue diseases, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), 0303 health sciences, education.field_of_study, variants, Multidisciplinary, Cancer Risk Factors, Obstetrics and Gynecology, Single Nucleotide, 3. Good health, Genetic Epidemiology, 030220 oncology & carcinogenesis, alleles, Medicine, Pair 6, Cancer Epidemiology, Research Article, Human, medicine.medical_specialty, SUSCEPTIBILITY LOCI, Science, Genetic Causes of Cancer, Population, Hereditary cancer and cancer-related syndromes Genetics and epigenetic pathways of disease [ONCOL 1], education, Single-nucleotide polymorphism, Chromosomes, 03 medical and health sciences, Breast cancer, SDG 3 - Good Health and Well-being, Translational research [ONCOL 3], Internal medicine, Breast Cancer, Genetics, Cancer Genetics, Genome-Wide Association Studies, medicine, GENOME-WIDE ASSOCIATION, Polymorphism, Genetics and epigenetic pathways of disease Translational research [NCMLS 6], gene, Biology, 030304 developmental biology, Cancer och onkologi, Population Biology, Hereditary cancer and cancer-related syndromes [ONCOL 1], Proportional hazards model, business.industry, Cancers and Neoplasms, Odds ratio, medicine.disease, GENE, Estrogen, susceptibility loci, Minor allele frequency, Cancer and Oncology, FGFR2, genome-wide association, 3111 Biomedicine, business |
| الوصف: | Recently, a locus on chromosome 6q22.33 (rs2180341) was reported to be associated with increased breast cancer risk in the Ashkenazi Jewish (AJ) population, and this association was also observed in populations of non-AJ European ancestry. In the present study, we performed a large replication analysis of rs2180341 using data from 31,428 invasive breast cancer cases and 34,700 controls collected from 25 studies in the Breast Cancer Association Consortium (BCAC). In addition, we evaluated whether rs2180341 modifies breast cancer risk in 3,361 BRCA1 and 2,020 BRCA2 carriers from 11 centers in the Consortium of Investigators of Modifiers of BRCA1/2 (CIMBA). Based on the BCAC data from women of European ancestry, we found evidence for a weak association with breast cancer risk for rs2180341 (per-allele odds ratio (OR) = 1.03, 95% CI 1.00-1.06, p = 0.023). There was evidence for heterogeneity in the ORs among studies (I-2 = 49.3%; p = less than0.004). In CIMBA, we observed an inverse association with the minor allele of rs2180341 and breast cancer risk in BRCA1 mutation carriers (per-allele OR = 0.89, 95% CI 0.80-1.00, p = 0.048), indicating a potential protective effect of this allele. These data suggest that that 6q22.33 confers a weak effect on breast cancer risk. |
| وصف الملف: | application/pdf; text |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2d9ace1bb1b1982e65b26c4b8604c1Test http://hdl.handle.net/11568/817750Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....db2d9ace1bb1b1982e65b26c4b8604c1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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