Neuroprotective Effects of Curcumin and Highly Bioavailable Curcumin on Oxidative Stress Induced by Sodium Nitroprusside in Rat Striatal Cell Culture
| العنوان: | Neuroprotective Effects of Curcumin and Highly Bioavailable Curcumin on Oxidative Stress Induced by Sodium Nitroprusside in Rat Striatal Cell Culture |
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| المؤلفون: | Toshiaki Kume, Akinori Akaike, Tadashi Hashimoto, Atsushi Imaizumi, Qand Agha Nazari, Yasuhiko Izumi, Yuki Takada-Takatori, Naotaka Izuo |
| المصدر: | Biological and Pharmaceutical Bulletin. 36:1356-1362 |
| بيانات النشر: | Pharmaceutical Society of Japan, 2013. |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Nitroprusside, Curcumin, Antioxidant, Iron, medicine.medical_treatment, Pharmaceutical Science, Pharmacology, medicine.disease_cause, Neuroprotection, chemistry.chemical_compound, Picrates, medicine, Animals, Rats, Wistar, Curcuma, Cytotoxicity, Cells, Cultured, L-Lactate Dehydrogenase, biology, Biphenyl Compounds, Free Radical Scavengers, General Medicine, Glutathione, biology.organism_classification, Corpus Striatum, Rats, Oxidative Stress, Neuroprotective Agents, chemistry, Biochemistry, Sodium nitroprusside, Oxidative stress, medicine.drug |
| الوصف: | Curcumin, a polyphenolic compound extracted from Curcuma longa, has several pharmacological activities such as anticancer, anti-inflammatory, and antioxidant effects. The purpose of this study was to investigate the protective effects of curcumin and THERACURMIN, a highly bioavailable curcumin, against sodium nitroprusside (SNP)-induced oxidative damage in primary striatal cell culture. THERACURMIN as well as curcumin significantly prevented SNP-induced cytotoxicity. To elucidate the cytoprotective effects of curcumin and THERACURMIN, we measured the intracellular glutathione level in striatal cells. Curcumin and THERACURMIN significantly elevated the glutathione level, which was decreased by treatment with SNP. Moreover, curcumin showed potent 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical-scavenging ability. Finally, a ferrozine assay showed that curcumin (10-100 µg/mL) has potent Fe(2+)-chelating ability. These results suggest that curcumin and THERACURMIN exert potent protective effects against SNP-induced cytotoxicity by free radical-scavenging and iron-chelating activities. |
| تدمد: | 1347-5215 0918-6158 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dae3bd69f8fe25b090f8322775e6d517Test https://doi.org/10.1248/bpb.b13-00300Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....dae3bd69f8fe25b090f8322775e6d517 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 13475215 09186158 |
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