Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1
| العنوان: | Regulation of Oxygen Homeostasis by Hypoxia-Inducible Factor 1 |
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| المؤلفون: | Gregg L. Semenza |
| المصدر: | Physiology. 24:97-106 |
| بيانات النشر: | American Physiological Society, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Hypoxia-Inducible Factor 1, Oxygen Consumption, Physiology, Oxygen homeostasis, HIV-1, Animals, Homeostasis, Humans, Biology, Hypoxia, Transcription factor, Signal Transduction, Cell biology |
| الوصف: | Metazoan organisms are dependent on a continuous supply of O2for survival. Hypoxia-inducible factor 1 (HIF-1) is a transcription factor that regulates oxygen homeostasis and plays key roles in development, physiology, and disease. HIF-1 activity is induced in response to continuous hypoxia, intermittent hypoxia, growth factor stimulation, and Ca2+signaling. HIF-1 mediates adaptive responses to hypoxia, including erythropoiesis, angiogenesis, and metabolic reprogramming. In each case, HIF-1 regulates the expression of multiple genes encoding key components of the response pathway. HIF-1 also mediates maladaptive responses to chronic continuous and intermittent hypoxia, which underlie the development of pulmonary and systemic hypertension, respectively. |
| تدمد: | 1548-9221 1548-9213 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dad2422a62f5012419b1d4a0c899ac61Test https://doi.org/10.1152/physiol.00045.2008Test |
| رقم الانضمام: | edsair.doi.dedup.....dad2422a62f5012419b1d4a0c899ac61 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15489221 15489213 |
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