Molecular pathology of thymomas: implications for diagnosis and therapy
| العنوان: | Molecular pathology of thymomas: implications for diagnosis and therapy |
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| المؤلفون: | Philipp Ströbel, Cleo-Aron Weis, Berthold Schalke, Djeda Belharazem, Zoran V. Popovic, Sebastian Schölch, Christoph Reißfelder, De-Hyung Lee, Alexander Marx, Yosuke Yamada |
| المصدر: | Virchows Archiv |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | 0301 basic medicine, Thymoma, Immune checkpoint inhibitors, DNA Mutational Analysis, chemical and pharmacologic phenomena, Biology, medicine.disease_cause, Pathology and Forensic Medicine, Autoimmunity, 03 medical and health sciences, 0302 clinical medicine, AIRE, SMARCA4, hemic and lymphatic diseases, microRNA, Biomarkers, Tumor, medicine, Humans, Pathology, Molecular, neoplasms, Myasthenia gravis, Molecular Biology, Molecular pathology, Point mutation, Microsatellite instability, MicroRNA, Thymus Neoplasms, Cell Biology, General Medicine, medicine.disease, Review and Perspectives, 030104 developmental biology, 030220 oncology & carcinogenesis, Mutation, Cancer research |
| الوصف: | Thymomas exhibit a unique genomic landscape, comprising the lowest on average total mutational burden among adult human cancers; a unique point mutation in the GTF2I gene in WHO type A and AB thymomas (and rarely others); almost unique KMT2A-MAML2 translocations in rare WHO type B2 and B3 thymomas; a unique YAP1-MAML2 translocation in almost all metaplastic thymomas; and unique miRNA profiles in relation to GTF2I mutational status and WHO histotypes. While most thymomas can be diagnosed solely on the basis of morphological features, mutational analyses can solve challenging differential diagnostic problems. No molecular biomarkers have been identified that predict the response of unresectable thymomas to chemotherapy or agents with known molecular targets. Despite the common and strong expression of PDL1 in thymomas, immune checkpoint inhibitors are rarely applicable due to the poor predictability of common, life-threatening autoimmune side effects that are related to the unrivaled propensity of thymomas towards autoimmunity. |
| وصف الملف: | application/pdf |
| تدمد: | 1432-2307 0945-6317 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da5bbbd0e833a2a1ea3a9ccdf6277823Test https://doi.org/10.1007/s00428-021-03068-8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....da5bbbd0e833a2a1ea3a9ccdf6277823 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14322307 09456317 |
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