MANAGEMENT OF ENDOCRINE DISEASE Subclinical hypothyroidism in children
| العنوان: | MANAGEMENT OF ENDOCRINE DISEASE Subclinical hypothyroidism in children |
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| المؤلفون: | Nicola Improda, Mariacarolina Salerno, Donatella Capalbo |
| المساهمون: | Salerno, Mariacarolina, Improda, Nicola, Capalbo, Donatella |
| المصدر: | European Journal of Endocrinology. 183:R13-R28 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Pediatric Obesity, PubMed, medicine.medical_specialty, Pediatrics, Adolescent, Endocrinology, Diabetes and Metabolism, Levothyroxine, Thyrotropin, 030209 endocrinology & metabolism, Reference range, Hashimoto Disease, Bone health, 03 medical and health sciences, Neonatal Screening, 0302 clinical medicine, Endocrinology, Hypothyroidism, Normal linear growth, Thyroid dysfunction, Internal medicine, medicine, Humans, False Positive Reactions, Endocrine Disease, Subclinical Hypothyroidism, Children, Child, Subclinical infection, Endocrine disease, business.industry, Infant, Newborn, Infant, General Medicine, Nutrition Surveys, medicine.disease, Thyroid Diseases, Iodine deficiency, Thyroxine, Child, Preschool, 030220 oncology & carcinogenesis, business, Iodine, medicine.drug |
| الوصف: | Subclinical hypothyroidism (SH) is biochemically defined as serum TSH levels above the upper limit of the reference range in the presence of normal free T4 (FT4) concentrations. While there is a general agreement to treat subjects with serum TSH levels above 10 mU/L, the management of mild form (TSH concentrations between 4.5 and 10 mU/L) is still a matter of debate. In children, mild SH is often a benign and remitting condition and the risk of progression to overt thyroid dysfunction depends on the underlying condition, being higher in the autoimmune forms. The major concern is to establish whether SH in children should always be considered an expression of mild thyroid dysfunction and may deserve treatment. Current data indicate that children with mild SH have normal linear growth, bone health and intellectual outcome. However, slight metabolic abnormalities and subtle deficits in specific cognitive domains have been reported in children with modest elevation of TSH concentration. Although these findings are not sufficient to recommend levothyroxine treatment for all children with mild SH, they indicate the need for regular monitoring to ensure early identification of children who may benefit from treatment. In the meanwhile, the decision to initiate therapy in children with mild SH should be based on individual factors. |
| تدمد: | 1479-683X 0804-4643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da4c76210b546f76ed40cbedbd793b26Test https://doi.org/10.1530/eje-20-0051Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....da4c76210b546f76ed40cbedbd793b26 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1479683X 08044643 |
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