Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome
| العنوان: | Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome |
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| المؤلفون: | Denisse L. Leyton, David C. Tscharke, Nadja Jessberger, Edward M. Fox, Abhimanu Pandey, Jason D. Price, Daniel Fox, Gaetan Burgio, Si Ming Man, Chinh Ngo, Jenni A. Hayward, Erwin Märtlbauer, Anukriti Mathur, Shouya Feng, Wei Hong Tan, Stephen H. Leppla, Yansong Xue, Ines Atmosukarto, Nadeem O. Kaakoush, Avril A. B. Robertson, Matthew D. Johnson, Yunqi Liu |
| المصدر: | Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020) Nature Communications |
| بيانات النشر: | Nature Portfolio, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Inflammasomes, Bacillus cereus, General Physics and Astronomy, Enterotoxin, Enterotoxins, Hemolysin Proteins, Mice, lcsh:Science, Mice, Knockout, Multidisciplinary, biology, integumentary system, Chemistry, Pyroptosis, Inflammasome, Hemolysin, C700, 3. Good health, Lytic cycle, Female, Pathogens, medicine.drug, Pattern recognition receptors, Virulence Factors, Science, 030106 microbiology, F100, Virulence, General Biochemistry, Genetics and Molecular Biology, Article, Host Specificity, Microbiology, Cell Line, 03 medical and health sciences, Bacterial Proteins, NLR Family, Pyrin Domain-Containing 3 Protein, medicine, Animals, Humans, Host Microbial Interactions, fungi, General Chemistry, C400, biology.organism_classification, Mice, Inbred C57BL, 030104 developmental biology, Bacillus haemolytic enterotoxin, bacteria, lcsh:Q |
| الوصف: | Inflammasomes are important for host defence against pathogens and homeostasis with commensal microbes. Here, we show non-haemolytic enterotoxin (NHE) from the neglected human foodborne pathogen Bacillus cereus is an activator of the NLRP3 inflammasome and pyroptosis. NHE is a non-redundant toxin to haemolysin BL (HBL) despite having a similar mechanism of action. Via a putative transmembrane region, subunit C of NHE initiates binding to the plasma membrane, leading to the recruitment of subunit B and subunit A, thus forming a tripartite lytic pore that is permissive to efflux of potassium. NHE mediates killing of cells from multiple lineages and hosts, highlighting a versatile functional repertoire in different host species. These data indicate that NHE and HBL operate synergistically to induce inflammation and show that multiple virulence factors from the same pathogen with conserved function and mechanism of action can be exploited for sensing by a single inflammasome. The Bacillus haemolytic enterotoxin haemolysin BL has been shown to activate the NLRP3 inflammasome. Here the authors show that a non-haemolytic enterotoxin (NHE) from B. cereus can also activate the NLRP3 inflammasome with a similar mechanism of lytic pore formation. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2041-1723 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9dbb01f431e801470a4eeb7526fb84fTest https://doaj.org/article/a3d1c668fd514f4c9ccf1972f0c941e9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d9dbb01f431e801470a4eeb7526fb84f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
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