Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up
| العنوان: | Gastrointestinal stromal tumours: ESMO-EURACAN Clinical Practice Guidelines for diagnosis, treatment and follow-up |
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| المؤلفون: | Casali, P.G., Abecassis, N., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Brodowicz, T., Broto, J.M., Buonadonna, A., Alava, E., Tos, A.P., Muro, X.G., Dileo, P., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hannu, A., Hassan, B., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kasper, B., Kopeckova, K., Krakorova, D.A., Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schoffski, P., Sleijfer, S., Stacchiotti, S., Hall, K.S., Unk, M., Coevorden, F., Graaf, W.D., Whelan, J., Wardelmann, E., Zaikova, O., Blay, J.Y., ESMO Guidelines Comm EURACAN |
| المساهمون: | Casali, P.G., Abecassis, N., Bauer, S., Biagini, R., Bielack, S., Bonvalot, S., Boukovinas, I., Bovee, J.V.M.G., Brodowicz, T., Broto, J.M., Buonadonna, A., De Álava, E., Dei Tos, A.P., Del Muro, X.G., Dileo, P., Eriksson, M., Fedenko, A., Ferraresi, V., Ferrari, A., Ferrari, S., Frezza, A.M., Gasperoni, S., Gelderblom, H., Gil, T., Grignani, G., Gronchi, A., Haas, R.L., Hannu, A., Hassan, B., Hohenberger, P., Issels, R., Joensuu, H., Jones, R.L., Judson, I., Jutte, P., Kaal, S., Kasper, B., Kopeckova, K., Krákorová, D.A., Le Cesne, A., Lugowska, I., Merimsky, O., Montemurro, M., Pantaleo, M.A., Piana, R., Picci, P., Piperno-Neumann, S., Pousa, A.L., Reichardt, P., Robinson, M.H., Rutkowski, P., Safwat, A.A., Schöffski, P., Sleijfer, S., Stacchiotti, S., Sundby Hall, K., Unk, M., Van Coevorden, F., Van Der Graaf, W., Whelan, J., Wardelmann, E., Zaikova, O., Blay, J.Y., Man, Biomaterials and Microbes (MBM), Public Health Research (PHR), Basic and Translational Research and Imaging Methodology Development in Groningen (BRIDGE), Heikki Joensuu / Principal Investigator, Department of Oncology, Clinicum, HUS Comprehensive Cancer Center, [Casali, P. G.] Fdn IRCCS Ist Nazl Tumori, Milan, Italy, [Frezza, A. M.] Fdn IRCCS Ist Nazl Tumori, Milan, Italy, [Gronchi, A.] Fdn IRCCS Ist Nazl Tumori, Milan, Italy, [Casali, P. G.] Univ Milan, Milan, Italy, [Frezza, A. M.] Univ Milan, Milan, Italy, [Gronchi, A.] Univ Milan, Milan, Italy, [Abecassis, N.] EPE, Inst Portugues Oncol Lisboa Francisco Gentil, Lisbon, Portugal, [Bauer, S.] Univ Hosp Essen, Essen, Germany, [Biagini, R.] Regina Elena Inst Canc Res, IFO, Musculoskeletal Tissue Bank, Dept Oncol Orthoped, Rome, Italy, [Bielack, S.] Olga Hosp, Klinikum Stuttgart, Stuttgart, Germany, [Bonvalot, S.] Inst Curie, Paris, France, [Piperno-Neumann, S.] Inst Curie, Paris, France, [Boukovinas, I.] NORDIX, Athens, Greece, [Bovee, J. V. M. G.] Leiden Univ, Med Ctr, Dept Pathol, Leiden, Netherlands, [Brodowicz, T.] Med Univ Wien, Vienna Gen Hosp AKH, Vienna, Austria, [Broto, J. M.] Hosp Univ Virgen Rocio, CIBERONC, Seville, Spain, [De Alava, E.] Hosp Univ Virgen Rocio, CIBERONC, Seville, Spain, [Buonadonna, A.] Ctr Riferimento Oncol Aviano, Aviano, Italy, [Dei Tos, A. P.] Osped Reg Treviso S Maria Ca Foncello, Treviso, Italy, [Del Muro, X. G.] HUB, ICO Hosp, Integrated Unit, Barcelona, Spain, [Dileo, P.] Univ Coll London Hosp, Sarcoma Unit, London, England, [Eriksson, M.] Skane Univ Hosp Lund, Lund, Sweden, [Fedenko, A.] NN Blokhin Russian Canc Res Ctr, Moscow, Russia, [Ferraresi, V.] Inst Sci Hosp Care, Regina Elena Natl Canc Inst, IRCCS, Rome, Italy, [Ferrari, A.] Fdn IRCCS Ist Nazl Tumori, Pediat Oncol Unit, Milan, Italy, [Ferrari, S.] Ist Ortoped Rizzoli, Bologna, Italy, [Picci, P.] Ist Ortoped Rizzoli, Bologna, Italy, [Gasperoni, S.] Univ Careggi Firenze, Azienda Osped, Florence, Italy, [Gelderblom, H.] Leiden Univ, Med Ctr, Dept Med Oncol, Leiden, Netherlands, [Gil, T.] Inst Jules Bordet, Brussels, Belgium, [Grignani, G.] IRCCS, FPO, Candiolo Canc Inst, Candiolo, Italy, [Haas, R. L.] Netherlands Canc Inst, Dept Radiotherapy, Amsterdam, Netherlands, [Haas, R. L.] Leiden Univ, Med Ctr, Dept Radiotherapy, Leiden, Netherlands, [Hannu, A.] Turku Univ Hosp, Turun Yliopistollinen Keskussairaala, Turlu, Finland, [Hassan, B.] Oxford Univ Hosp NHS Fdn Trust, Oxford, England, [Hohenberger, P.] Mannheim Univ, Med Ctr, Mannheim, Germany, [Kasper, B.] Mannheim Univ, Med Ctr, Mannheim, Germany, [Issels, R.] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Med 3, Munich, Germany, [Joensuu, H.] Univ Helsinki, Cent Hosp, HUCH, Helsinki, Finland, [Jones, R. L.] Royal Marsden Hosp, London, England, [Van der Graaf, W.] Royal Marsden Hosp, London, England, [Judson, I.] Inst Canc Res, London, England, [Jutte, P.] Univ Med Ctr Groningen, Groningen, Netherlands, [Kaal, S.] Radboud Univ Nijmegen, Med Ctr, Nijmegen, Netherlands, [Kopeckova, K.] Univ Hosp Motol, Prague, Czech Republic, [Krakorova, D. A.] Masaryk Mem Canc Inst, Brno, Czech Republic, [Le Cesne, A.] Gustave Roussy Canc Campus, Villejuif, France, [Lugowska, I.] Marie Sklodowska Curie Inst, Oncol Ctr, Warsaw, Poland, [Rutkowski, P.] Marie Sklodowska Curie Inst, Oncol Ctr, Warsaw, Poland, [Merimsky, O.] Tel Aviv Sourasky Med Ctr Ichilov, Tel Aviv, Israel, [Montemurro, M.] Univ Hosp Lausanne, Med Oncol, Lausanne, Switzerland, [Pantaleo, M. A.] Univ Bologna, Policlin S Orsola Malpighi, Azienda Osped, Bologna, Italy, [Piana, R.] Univ Cita Salute & Sci Torino, Azienda Osped, Turin, Italy, [Pousa, A. L.] Hosp Santa Creu & Sant Pau, Fundacio Gestio Sanitaria, Barcelona, Spain, [Reichardt, P.] Helios Klinikum Berlin Buch, Berlin, Germany, [Robinson, M. H.] Weston Pk Hosp NHS Trust, Dept Clin Oncol, YCRC, Sheffield, S Yorkshire, England, [Safwat, A. A.] Aarhus Univ Hosp, Aarhus, Denmark, [Schoffski, P.] Leuven Canc Inst, Leuven, Belgium, [Sleijfer, S.] Erasmus MC Canc Inst, Dept Med Oncol, Rotterdam, Netherlands, [Stacchiotti, S.] Ist Nazl Tumori, Fdn Ist Ricovero & Cura Carattere Sci, Milan, Italy, [Hall, K. Sundby] Norwegian Radium Hosp, Oslo Univ Hosp, Dept Oncol, Oslo, Norway, [Unk, M.] Inst Oncol Ljubljana, Ljubljana, Slovenia, [Van Coevorden, F.] Netherlands Canc Inst Antoni van Leeuwenhoek, Amsterdam, Netherlands, [Whelan, J.] Univ Coll Hosp, London, England, [Wardelmann, E.] Univ Klinikum Munster, Gerhard Domagk Inst Pathol, Munster, Germany, [Zaikova, O.] Norwegian Radium Hosp, Oslo Univ Hosp, Oslo, Norway, [Blay, J. Y.] Ctr Leon Bernard, Lyon, France, [Blay, J. Y.] UCBL1, Lyon, France, Amgen Dompe, AROG Bayer, Blueprint Medicines, Eli Lilly, Daiichi Sankyo Pharma, Epizyme, GlaxoSmithKline, Novartis, Pfizer, PharmaMar, Incyte, Lilly, Bayer, Janssen-Cilag, Eisai, Loxo Oncology, Nanobiotix, Bristol-Myers Squibb, Merck Sharp Dohme, Roche, Amgen, EuroSarc, CoBioRes, Exelixis, Plexxikon, Sixth Element Capital, Adaptaimmune, Amcure, AstraZeneca, Boehringer Ingelheim, Cristal Therapeutics, Daichii Sankyo Pharma, Genzyme, Ipsen, Medpace, Nektar, Philogen, Piqur Therapeutics, Swedish Orphan Biovitrium, Advenchen, Epizyme Inc., PharmarMar, Novartis Oncology, Milestone, Menarini, Medical Oncology |
| المصدر: | Annals of Oncology, 29, iv68-iv78 Annals of Oncology, 29, Supplement_4, pp. iv68-iv78 Annals of Oncology, 29, 68-78 ANNALS OF ONCOLOGY r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname Annals of Oncology, 29, 68-78. Oxford University Press Annals of Oncology, 29, 68-78. Elsevier Ltd. |
| بيانات النشر: | Elsevier, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | SURGERY, medicine.medical_treatment, Medizin, Aftercare, Medical Oncology, law.invention, DOSE IMATINIB, Endosonography, 0302 clinical medicine, Randomized controlled trial, law, Recurrence, Antineoplastic Combined Chemotherapy Protocols, Medicine, Digestive System Surgical Procedures, Societies, Medical, Adjuvant imatinib, NEOADJUVANT/ADJUVANT IMATINIB MESYLATE, GiST, Progression, Incidence, Stomach, Margins of Excision, KIT, Hematology, Gastrointestinal stromal tumours, 3. Good health, Clinical Practice, Europe, Intestines, Self-Help Groups, Treatment Outcome, Diagnosis treatment, Oncology, Chemotherapy, Adjuvant, 030220 oncology & carcinogenesis, 030211 gastroenterology & hepatology, ADJUVANT IMATINIB, Neoadjuvant/adjuvant imatinib mesylate, PHASE-II TRIAL, Mutations, Rare cancers Radboud Institute for Health Sciences [Radboudumc 9], GIST, Adult, Image-Guided Biopsy, medicine.medical_specialty, Gastrointestinal Stromal Tumors, education, 3122 Cancers, 03 medical and health sciences, Stomach surgery, Carney-stratakis, CARNEY-STRATAKIS, Humans, Gist, Neoplasm Staging, Chemotherapy, business.industry, MUTATIONS, General surgery, ta3121, RANDOMIZED-TRIAL, digestive system diseases, Imatinib mesylate, Phase-ii trial, 3121 General medicine, internal medicine and other clinical medicine, Surgery, Laparoscopy, Patient Participation, business, Dose imatinib, Tomography, X-Ray Computed |
| الوصف: | Gastrointestinal stromal tumours (GISTs) are rare tumours, with an estimated unadjusted incidence of around 1/100 000/year. This only covers clinically relevant GISTs, since, if investigated, amuch higher number of lesions ≤ 1 cmin diameter (microGISTs) can be found at histopathological examination of stomach tissue in middle-aged and elderly individuals. There is a slight prevalence in males. The median age is around 60–65 years, with a wide range. Occurrence in children is very rare. Paediatric GIST represents a clinically and molecularly distinct subset, marked by female predominance, absence of KIT/platelet- derived growth factor alpha (PDGFRA) mutations, frequent mutations or silencing of the four genes that encode the subunits of the succinate dehydrogenase (SDH) enzyme complex, gastric multicentric location and possible lymph node metastases. Some syndromes are linked to GISTs: • The Carney triad syndrome, marked by gastric GISTs, paraganglioma and pulmonary chondromas (these may occur at different ages); • Carney–Stratakis syndrome, marked by a dyad of GIST and paraganglioma; and • Neurofibromatosis type 1(NF1), possibly leading to wild-type (WT), often multicentric GIST, predominantly located in the small bowel Families with germline autosomal dominant mutations of KIT are an extremely rare finding, presenting with multiple GISTs at an early age, possibly along with other associated features such as pigmented skin macules, urticaria pigmentosa and diffuse hyperplasia of the interstitial cells of Cajal in the gut wall. |
| وصف الملف: | ELETTRONICO |
| اللغة: | English |
| تدمد: | 0923-7534 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9705c9164199c5339b8a4b2dd980f8aTest https://ora.ox.ac.uk/objects/uuid:17842f8f-8914-49d9-8c8f-c91fc9a08743Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d9705c9164199c5339b8a4b2dd980f8a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09237534 |
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