High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1
| العنوان: | High HTLV-1 proviral load, a marker for HTLV-1 associated myelopathy/tropical spastic paraparesis, is also detected in patients with infective dermatitis associated with HTLV-1 |
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| المؤلفون: | Edgar M. Carvalho, Lourdes Farre, Isadora Cristina de Siqueira, Márcia Nascimento, Achiléa L. Bittencourt, Janeusa Rita L. Primo, Maria de Fátima Santos Paim de Oliveira |
| المصدر: | Brazilian Journal of Medical and Biological Research. 42:761-764 |
| بيانات النشر: | FapUNIFESP (SciELO), 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, Male, Adolescent, Physiology, Immunology, Population, Biophysics, Dermatitis, Ocean Engineering, Biochemistry, Asymptomatic, Article, Myelopathy, Proviruses, Risk Factors, immune system diseases, hemic and lymphatic diseases, Tropical spastic paraparesis, medicine, Humans, General Pharmacology, Toxicology and Pharmaceutics, Child, education, Human T-lymphotropic virus 1, education.field_of_study, biology, business.industry, General Neuroscience, virus diseases, Cell Biology, General Medicine, Viral Load, medicine.disease, biology.organism_classification, Paraparesis, Tropical Spastic, Lymphoma, Leukemia, Child, Preschool, Carrier State, DNA, Viral, Skin Diseases, Viral, Disease Progression, Female, medicine.symptom, business, Viral load, Biomarkers |
| الوصف: | Salvador (BA, Brazil) is an endemic area for human T-cell lymphotrophic virus type 1 (HTLV-1). The overall prevalence of HTLV-1 infection in the general population has been estimated to be 1.76%. HTLV-1 carriers may develop a variety of diseases such as adult T-cell leukemia/lymphoma, HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and infective dermatitis associated with HTLV-1 (IDH). IDH is a chronic and severe form of childhood exudative and infective dermatitis involving mainly the scalp, neck and ears. It has recently been observed that 30% of patients with IDH develop juvenile HAM/TSP. The replication of HTLV-1 has been reported to be greater in adult HAM/TSP patients than in asymptomatic HTLV-1 carriers. In the current study, the proviral load of 28 children and adolescents with IDH not associated with HAM/TSP was determined and the results were compared to those obtained in 28 HTLV-1 adult carriers and 28 adult patients with HAM/TSP. The proviral load in IDH patients was similar to that of patients with HAM/TSP and much higher than that found in HTLV-1 carriers. The high levels of proviral load in IDH patients were not associated with age, duration of illness, duration of breast-feeding, or activity status of the skin disease. Since proviral load is associated with neurological disability, these data support the view that IDH patients are at high risk of developing HAM/TSP. |
| تدمد: | 1414-431X 0100-879X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95c7f4be85692bfffc266db84d562a3Test https://doi.org/10.1590/s0100-879x2009005000008Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d95c7f4be85692bfffc266db84d562a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1414431X 0100879X |
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