Partial Clinical Remission Reduces Lipid-Based Cardiovascular Risk in Adult Patients With Type 1 Diabetes
| العنوان: | Partial Clinical Remission Reduces Lipid-Based Cardiovascular Risk in Adult Patients With Type 1 Diabetes |
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| المؤلفون: | Austin F Lee, Benjamin U. Nwosu, Layana Al-Halbouni, Gabrielle Jasmin, Sadichchha Parajuli, Krish Khatri |
| المصدر: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) |
| بيانات النشر: | Frontiers Media SA, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, endocrine system diseases, Adolescent, type 1 diabetes, Cvd risk, Endocrinology, Diabetes and Metabolism, Type 2 diabetes, Gastroenterology, Diseases of the endocrine glands. Clinical endocrinology, Young Adult, Endocrinology, Internal medicine, adults, medicine, Humans, honeymoon phase, Original Research, Aged, Dyslipidemias, Retrospective Studies, Type 1 diabetes, Adult patients, Atherosclerotic cardiovascular disease, business.industry, dyslipidemia, Remission Induction, nutritional and metabolic diseases, Middle Aged, RC648-665, Atherosclerosis, Prognosis, medicine.disease, Lipids, Obesity, cardiovascular disease risk, Diabetes Mellitus, Type 1, Cardiovascular Diseases, Heart Disease Risk Factors, Case-Control Studies, Cohort, Female, type 2 diabetes, business, Biomarkers, Dyslipidemia, partial clinical remission, Follow-Up Studies |
| الوصف: | ImportanceRisk factors for atherosclerotic cardiovascular disease (ASCVD) are well established in type 2 diabetes (T2D), but not in type 1 diabetes (T1D). The impact of partial clinical remission (PR) on short-term ASCVD risk in T1D is unclear.AimTo investigate the impact of PR on the earliest ASCVD risk phenotype in adult T1D using factor analysis to compare the lipid phenotypes of T1D, T2D and controls after stratifying the T1D cohort into remitters and non-remitters.Subjects and MethodsA study of 203 adults subjects consisting of 86 T2D subjects, and 77 T1D subjects stratified into remitters (n=49), and non-remitters (n=28). PR was defined as insulin-dose adjusted HbA1c of ≤9, and obesity as a BMI ≥30 kg/m2. Factor analysis was used to stratify the groups by ASCVD risk by factorizing seven lipid parameters (TC, LDL, HDL, non-HDL, TC/HDL, TG, TG/HDL) into 2 orthogonal factors (factor 1: TC*LDL; factor 2: HDL*TG) that explained 90% of the variance in the original seven parameters.ResultsThe analysis of individual lipid parameters showed that TC/HDL was similar between the controls and remitters (p=NS) but was significantly higher in the non-remitters compared to the remitters (p=0.026). TG/HDL was equally similar between the controls and remitters (p=NS) but was lower in the remitters compared to the non-remitters (p=0.007). TG was significantly lower in the remitters compared to T2D subjects (pversusnon-remitters (p=0.0003) but was similar between the controls and remitters (p=NS). Factor analysis showed that the means of factor 1 and factor 2 composite scores for dyslipidemia increased linearly from the controls, remitters, non-remitters to T2D, p value 0.0042 for factor 1, and ConclusionsPartial clinical remission of T1D is associated with a favorable early lipid phenotype which could translate to reduced long-term CVD risk in adults. |
| تدمد: | 1664-2392 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d95a0054f8385215a4e64574c801649aTest https://doi.org/10.3389/fendo.2021.705565Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d95a0054f8385215a4e64574c801649a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16642392 |
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