Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities
| العنوان: | Autoimmune antibodies correlate with immune checkpoint therapy-induced toxicities |
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| المؤلفون: | Jianjun Gao, Hao Zhao, Rebecca S. S. Tidwell, Emily Z. Keung, Yuji Miura, Salahaldin A. Tahir, Sumit K. Subudhi, Hussein Abdul-Hassan Tawbi, Jennifer A. Wargo, James P. Allison, Padmanee Sharma, Jorge Blando |
| المصدر: | Proceedings of the National Academy of Sciences. 116:22246-22251 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, Hypophysitis, GTP-Binding Protein alpha Subunits, Gi-Go, Serology, 03 medical and health sciences, 0302 clinical medicine, Neoplasms, medicine, Humans, Autoimmune Hypophysitis, Adverse effect, Adaptor Proteins, Signal Transducing, Aged, Autoantibodies, Pneumonitis, Multidisciplinary, biology, business.industry, Autoantibody, Cancer, Pneumonia, Middle Aged, Biological Sciences, medicine.disease, Immune checkpoint, 030104 developmental biology, 030220 oncology & carcinogenesis, Immunology, biology.protein, Female, Immunotherapy, Antibody, business, Biomarkers |
| الوصف: | Immune checkpoint (IC) therapy provides substantial benefits to cancer patients but can also cause distinctive toxicities termed immune-related adverse events (irAEs). Biomarkers to predict toxicities will be necessary to improve management of patients receiving IC therapy. We relied on serological analysis of recombinant cDNA expression libraries to evaluate plasma samples from patients treated with IC therapy and identified autoantibodies, both in pretreatment and on-treatment samples prior to the development of irAEs, which correlate with the development of immune-related hypophysitis (anti-GNAL and anti-ITM2B autoantibodies) and pneumonitis (anti-CD74 autoantibody). We developed an enzyme-linked immunosorbent assay and tested additional patient samples to confirm our initial findings. Collectively, our data suggest that autoantibodies may correlate with irAEs related to IC therapy, and specific autoantibodies may be detected early for the management of irAEs. |
| تدمد: | 1091-6490 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d90d6f7c8309fb1f0e94af9eb497603cTest https://doi.org/10.1073/pnas.1908079116Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d90d6f7c8309fb1f0e94af9eb497603c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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