Postoperative cognitive change after cardiac surgery predicts long‐term cognitive outcome
| العنوان: | Postoperative cognitive change after cardiac surgery predicts long‐term cognitive outcome |
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| المؤلفون: | Juhani Rämö, Kari-Pekka Saastamoinen, Risto O. Roine, Antti Vento, Lauri Soinne, Marja Hietanen, Kirsi Rantanen, Kristiina Relander |
| المساهمون: | Clinicum, Department of Neurosciences, University of Helsinki, Helsinki University Hospital Area, HUS Neurocenter, Neurologian yksikkö, III kirurgian klinikka, HUS Heart and Lung Center, Department of Surgery |
| المصدر: | Brain and Behavior Brain and Behavior, Vol 10, Iss 9, Pp n/a-n/a (2020) |
| بيانات النشر: | John Wiley and Sons Inc., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | neuropsychological tests, Male, medicine.medical_specialty, DISEASE, 3124 Neurology and psychiatry, 050105 experimental psychology, ARTERY-BYPASS GRAFT, lcsh:RC321-571, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Cognition, Postoperative Complications, cognitive dysfunction, Internal medicine, cognition disorders, medicine, risk factors, Humans, 0501 psychology and cognitive sciences, Effects of sleep deprivation on cognitive performance, Postoperative Period, Cognitive decline, Risk factor, CABG, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Original Research, NEUROCOGNITIVE FUNCTION, DECLINE, medicine.diagnostic_test, business.industry, 05 social sciences, 3112 Neurosciences, Neuropsychology, Infant, Neuropsychological test, medicine.disease, DYSFUNCTION, 3. Good health, Cardiac surgery, coronary artery bypass, Cardiology, BEHAVIORAL FUNCTIONAL-CAPACITY, business, Postoperative cognitive dysfunction, 030217 neurology & neurosurgery |
| الوصف: | Objectives Postoperative cognitive dysfunction (POCD) is a common consequence of coronary artery bypass grafting. However, domain‐specific associations between postoperative changes and long‐term performance are poorly known. The aim of this study was to investigate whether domain‐specific cognitive changes after cardiac surgery predict long‐term cognitive outcome. Materials and Methods We assessed 100 patients (86 men, mean age 60) before coronary artery bypass grafting, with re‐examinations after one week, three months, and a mean of 6.7 years. The extensive neuropsychological test battery was organized into seven functional cognitive domains. Cognitive decline and improvement were defined with the reliable change index derived from 17 matching healthy controls. Analyses were adjusted for baseline cognitive performance, age, gender, education and cardiovascular risks factors. Results On group level, one week after surgery 71% patients showed cognitive decline and 9% improvement in any functional domain, as compared to preoperative results. Three months postsurgery, decline was observed in 47% and improvement in 25% of patients. Executive functioning was the most sensitive domain to both decline and improvement. Postoperative dysfunction predicted long‐term cognitive deterioration six years after operation, particularly in the domain of executive functioning. Conclusions POCD after coronary artery bypass grafting is an essential risk factor for long‐term deterioration and an indication for neuropsychological follow‐up. Assessment of change in executive functioning after coronary artery bypass grafting may help to identify patients at risk for unfavorable long‐term outcome. The aim of this study was to investigate whether domain‐specific cognitive changes after cardiac surgery predict long‐term cognitive outcome. We assessed 100 patients before coronary artery bypass grafting, with re‐examinations after one week, three months, and six years. Postoperative dysfunction predicted long‐term cognitive deterioration six years after operation, particularly in the domain of executive functioning. |
| اللغة: | English |
| تدمد: | 2162-3279 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d904e844ea347d31e00f836a090549f1Test http://europepmc.org/articles/PMC7507551Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d904e844ea347d31e00f836a090549f1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 21623279 |
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