Reversing the Psychiatric Effects of Neurodevelopmental Cannabinoid Exposure: Exploring Pharmacotherapeutic Interventions for Symptom Improvement
| العنوان: | Reversing the Psychiatric Effects of Neurodevelopmental Cannabinoid Exposure: Exploring Pharmacotherapeutic Interventions for Symptom Improvement |
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| المؤلفون: | Marta De Felice, Steven R. Laviolette |
| المصدر: | International Journal of Molecular Sciences, Vol 22, Iss 7861, p 7861 (2021) International Journal of Molecular Sciences |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | cannabis, medicine.medical_treatment, Psychological intervention, Review, 0302 clinical medicine, Dronabinol, endocannabinoid system, Biology (General), Spectroscopy, biology, neurodevelopment, General Medicine, 3. Good health, Computer Science Applications, Chemistry, psychiatric disorders, Schizophrenia, Anxiety, medicine.symptom, Psychopathology, medicine.medical_specialty, THC, GABA Agents, QH301-705.5, Psychology, Adolescent, Catalysis, Inorganic Chemistry, 03 medical and health sciences, mesocorticolimbic system, mental disorders, medicine, Animals, Humans, Physical and Theoretical Chemistry, Psychiatry, Molecular Biology, QD1-999, business.industry, Organic Chemistry, biology.organism_classification, medicine.disease, 030227 psychiatry, Mood, Neurodevelopmental Disorders, Endophenotype, adolescence, Cannabis, Cannabinoid, business, marijuana, 030217 neurology & neurosurgery |
| الوصف: | Neurodevelopmental exposure to psychoactive compounds in cannabis, specifically THC, is associated with a variety of long-term psychopathological outcomes. This increased risk includes a higher prevalence of schizophrenia, mood and anxiety disorders, and cognitive impairments. Clinical and pre-clinical research continues to identify a wide array of underlying neuropathophysiological sequelae and mechanisms that may underlie THC-related psychiatric risk vulnerability, particularly following adolescent cannabis exposure. A common theme among these studies is the ability of developmental THC exposure to induce long-term adaptations in the mesocorticolimbic system which resemble pathological endophenotypes associated with these disorders. This narrative review will summarize recent clinical and pre-clinical evidence that has elucidated these THC-induced developmental risk factors and examine how specific pharmacotherapeutic interventions may serve to reverse or perhaps prevent these cannabis-related risk outcomes. |
| اللغة: | English |
| تدمد: | 1661-6596 1422-0067 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d84cc4041cc153fb3713c5da1b38e046Test https://www.mdpi.com/1422-0067/22/15/7861Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d84cc4041cc153fb3713c5da1b38e046 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16616596 14220067 |
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