Prevalence of Delta-Like Protein 3 in a Consecutive Series of Surgically Resected Lung Neuroendocrine Neoplasms
| العنوان: | Prevalence of Delta-Like Protein 3 in a Consecutive Series of Surgically Resected Lung Neuroendocrine Neoplasms |
|---|---|
| المؤلفون: | Federico Davini, S. Ricci, Greta Alì, Anello Marcello Poma, Marco Lucchi, Franca Melfi, Iosè Di Stefano, Agnese Proietti, Gabriella Fontanini |
| المصدر: | Frontiers in Oncology, Vol 11 (2021) Frontiers in Oncology |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, medicine.medical_specialty, Neuroendocrine tumors, Gastroenterology, delta-like protein 3, Internal medicine, medicine, Stage (cooking), RC254-282, Original Research, Lung, biology, biomarker, immunohistochemistry, lung neuroendocrine tumors, prognosis, business.industry, Chromogranin A, Cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, medicine.anatomical_structure, Oncology, biology.protein, Biomarker (medicine), Immunohistochemistry, Small Cell Lung Carcinoma, business |
| الوصف: | Delta-like protein 3 (DLL3) is a protein of the Notch pathway, and it is a potential therapeutic target for high-grade lung neuroendocrine tumors (NETs), i.e., small cell lung carcinoma (SCLC) and large cell neuroendocrine carcinoma (LCNEC). However, DLL3 prevalence in lung NETs and its association with clinicopathological characteristics and prognosis remained unclear. We analyzed the immunohistochemical expression of DLL3 and its prognostic role in a consecutive series of 155 surgically resected lung NETs, including typical carcinoid (TC), atypical carcinoid (AC), LCNEC, and SCLC patients. The DLL3 expression was categorized as high (>50% positive tumor cells) or low (vs. |
| اللغة: | English |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d81a184f34a20d2869ae7c1b7fd6a74dTest http://hdl.handle.net/11568/1113690Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d81a184f34a20d2869ae7c1b7fd6a74d |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |