Comparison of outcomes between metaplastic and triple-negative breast cancer patients
| العنوان: | Comparison of outcomes between metaplastic and triple-negative breast cancer patients |
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| المؤلفون: | Mary R. Schwartz, V. Suzanne Klimberg, Waqar Haque, E. Brian Butler, Kevin Cao, Bin S. Teh, Praveen Polamraju, Sandra S. Hatch, Vivek Verma, Polly A. Niravath |
| المصدر: | Breast, Vol 49, Iss, Pp 8-16 (2020) The Breast : official journal of the European Society of Mastology |
| بيانات النشر: | Elsevier, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Oncology, medicine.medical_specialty, Databases, Factual, medicine.medical_treatment, Triple Negative Breast Neoplasms, Disease, lcsh:RC254-282, Breast cancer, Metaplastic, Internal medicine, medicine, Humans, Chemotherapy, Stage (cooking), skin and connective tissue diseases, Triple-negative breast cancer, Aged, Retrospective Studies, Aged, 80 and over, Proportional hazards model, business.industry, Carcinoma, Ductal, Breast, Cancer, General Medicine, Middle Aged, Prognosis, medicine.disease, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Combined Modality Therapy, Survival Analysis, United States, Radiation therapy, Logistic Models, Case-Control Studies, Multivariate Analysis, Triple-negative, Female, Original Article, Surgery, business |
| الوصف: | Purpose Metaplastic breast cancer (MBC) is a rare, aggressive variant of breast cancer that has been associated with poor clinical outcomes, as has triple-negative breast (TNBC) cancer. Limited studies compare the clinical characteristics and prognosis of MBC to TNBC. This study uses a large, contemporary US cancer database to compare clinical characteristics and survival outcomes for patients with MBC to those with TNBC. Methods The National Cancer Database was queried for women with cT1-4N1-3M0 MBC or TNBC diagnosed between 2004 and 2013 and treated with definitive surgery. Chi-squared analysis was performed to determine differences between the cohorts. Kaplan-Meier curves compared overall survival (OS), and Cox regression determined patient factors associated with OS. Results Altogether, 55,847 patients met the inclusion criteria; 50,705 (90.8%) had TNBC and 5,142 (9.2%) had MBC. Most patients had no comorbid conditions (82%), N0 disease (71%), poorly differentiated histology (77%), received chemotherapy (87%), and received radiation therapy (60%). Amongst all patients, patients with TNBC disease were observed to have greater OS than those with MBC (5-year OS 72.0% vs 55.8%, p Highlights • Metaplastic breast cancer is associated with poor clinical outcomes. • Metaplastic breast cancer associated with worse survival than patients with triple negative invasive ductal carcinoma. • Radiation therapy and chemotherapy associated with improved survival for patients with metaplastic breast cancer. |
| اللغة: | English |
| تدمد: | 1532-3080 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c03e83793456d42a70c1bfa4bc050aTest http://www.sciencedirect.com/science/article/pii/S0960977619305661Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d7c03e83793456d42a70c1bfa4bc050a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15323080 |
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