Relationships Between Placental Lipid Activated/Transport-Related Factors and Macrosomia in Healthy Pregnancy
العنوان: | Relationships Between Placental Lipid Activated/Transport-Related Factors and Macrosomia in Healthy Pregnancy |
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المؤلفون: | Li-Fang Ni, Ying Han, Yu-Huan Wang, Tian Zheng, Xin-Jun Yang, Yan Ye, Miao-Miao Ding, Chen-Chen Wang, Hong-Tao Yan |
المصدر: | Reproductive Sciences. 29:904-914 |
بيانات النشر: | Springer Science and Business Media LLC, 2021. |
سنة النشر: | 2021 |
مصطلحات موضوعية: | Adult, medicine.medical_specialty, Placenta, CD36, Blood lipids, Umbilical cord, Fetal Macrosomia, NEFA, Pregnancy, Internal medicine, medicine, Fetal macrosomia, Humans, chemistry.chemical_classification, biology, business.industry, Infant, Newborn, Obstetrics and Gynecology, Fatty acid, Fatty Acid Transport Proteins, Fetal Blood, medicine.disease, medicine.anatomical_structure, Endocrinology, chemistry, Case-Control Studies, Cord blood, biology.protein, Female, business |
الوصف: | To assess associations between infants with macrosomia and placental expression levels of lipid activated/transport-related factors and umbilical cord blood lipid concentrations in healthy pregnancy. We conducted a case-control study of 38 macrosomic neonates (MS group) and 39 normal-birth-weight newborns (NC group) in a healthy pregnancy. Cord blood lipid levels were measured by automatic biochemical analyzer, mRNA and protein expression levels of placental lipid activated/transport-related factors were determined by real-time polymerase chain reaction and western blot, respectively. Compared with NC group, cord blood total cholesterol (TC), low-density lipoprotein cholesterol (LDLC), and non-esterified fatty acid (NEFA) concentrations were decreased in the MS group. The mRNA and protein expression levels of placental peroxisome proliferator-activated receptors (PPARα, PPARγ), plasma membrane fatty acid-binding protein (FABPpm), and fatty acid translocase (FAT/CD36) were significantly higher in the MS group than the NC group. And there was a weak positive correlation between the expression of PPARγ, FABP4, and FABP3 mRNA in the placenta and the HDLC (rs = 0.439; P = 0.005), NEFA (rs = 0.342; P = 0.041), and TG (rs = 0.349; P = 0.034) levels in the cord blood in the MS group, respectively. After multivariate adjustment, the logistic regression analysis showed that high placental PPARα (adjusted odds ratio [AOR] = 3.022; 95% confidence interval [CI] 1.032-8.853) and FAT/CD36 (AOR=2.989; 95%CI 1.029-8.679) and low LDLC concentration in the cord blood (AOR=0.246; 95%CI 0.080-0.759) increased the risk of macrosomia. The increased PPARα and FAT/CD36 expression levels may influence the occurrence of fetal macrosomia through regulating placental lipid transport. |
تدمد: | 1933-7205 1933-7191 |
الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d76196e9bb671ee498d3cfb65129fb31Test https://doi.org/10.1007/s43032-021-00755-4Test |
حقوق: | CLOSED |
رقم الانضمام: | edsair.doi.dedup.....d76196e9bb671ee498d3cfb65129fb31 |
قاعدة البيانات: | OpenAIRE |
تدمد: | 19337205 19337191 |
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