التفاصيل البيبلوغرافية
العنوان:
Itch: a HECT-type E3 ligase regulating immunity, skin and cancer
المؤلفون:
Gareth J. Browne , Loredana Zocchi , Martina Malatesta , Aaron Ciechanover , Francesca Bernassola , Angelo Peschiaroli , Ewen Gallagher , Richard A. Knight , Mario Rossi , Rami I. Aqeilan , Flavia Scialpi , Gerry Melino
المصدر:
Cell death and differentiation . 15(7)
سنة النشر:
2008
مصطلحات موضوعية:
adaptor protein , cytokine , mutant protein , Notch receptor , protein c jun , protein Itch , regulator protein , transcription factor , transforming growth factor beta , ubiquitin protein ligase E3 , apoptosis , autoimmune disease , autoimmunity , binding affinity , carboxy terminal sequence , cell differentiation , cell fate , cell growth , cell proliferation , cell renewal , cell stress , clonal anergy , disease course , DNA damage , enzyme activation , enzyme activity , enzyme analysis , enzyme localization , enzyme specificity , enzyme substrate , epidermis cell , gene expression regulation , gene mutation , growth regulation , human , immune response , immunological tolerance , immunopathogenesis , immunopathology , immunoregulation , inflammation , keratinocyte , lung disease , lymphocyte differentiation , malignant neoplastic disease , malignant transformation , mutational analysis , nonhuman , pathophysiology , priority journal , protein binding , protein degradation , protein expression , protein family , protein phosphorylation , protein processing , protein protein interaction , protein stability , regulatory mechanism , review , signal transduction , skin disease , T lymphocyte activation , transcription regulation , ubiquitination , Animals , Cell Death , Immune System , Keratinocytes , Mice , Mice, Mutant Strains , Neoplasms , Phosphorylation , Protein Transport , Receptor, Epidermal Growth Factor , Receptors, Chemokine , Repressor Proteins , Signal Transduction , Skin , Substrate Specificity , Transforming Growth Factor beta , TRPC Cation Channels , Ubiquitin , Ubiquitin-Protein Ligases , Agouti , Mus , skin and connective tissue diseases , Settore BIO/11 , Ubiquitin ligase , ErbB Receptors , Molecular Biology , Epidermal Growth Factor , Immunology , Chemokine , Receptors , biology , Mutant Strains , medicine.symptom , Signal transduction , Receptor , Inflammation , Immune system , Immunity , medicine , Cell Biology , Transforming growth factor beta , biology.protein
الوصف:
The HECT-type E3 ubiquitin ligase (E3) Itch is absent in the non-agouti-lethal 18H or Itchy mice, which develop a severe immunological disease, including lung and stomach inflammation and hyperplasia of lymphoid and hematopoietic cells. The involvement of Itch in multiple signaling pathways and pathological conditions is presently an area of extensive scientific interest. This review aims to bring together a growing body of work exploring Itch-regulated biological processes, and to highlight recent discoveries on the regulatory mechanisms modulating its catalytic activity and substrate recognition capability. Our contribution is also an endeavor to correlate Itch substrate specificity with the pathological defects manifested by the mutant Itchy mice.
تدمد:
1350-9047
الوصول الحر:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d75d8a9d69263a342ecb749494c14652Test https://pubmed.ncbi.nlm.nih.gov/18552861Test
حقوق:
OPEN
رقم الانضمام:
edsair.doi.dedup.....d75d8a9d69263a342ecb749494c14652
قاعدة البيانات:
OpenAIRE
