Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases in an elderly population: outcomes from a single centre
| العنوان: | Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases in an elderly population: outcomes from a single centre |
|---|---|
| المؤلفون: | Michael P. Flood, Vignesh Narasimhan, Peadar S. Waters, Joseph C. Kong, Robert Ramsay, Michael Michael, Jeanne Tie, Jacob J. McCormick, Satish K. Warrier, Alexander G. Heriot |
| المصدر: | ANZ Journal of Surgery. 92:2192-2198 |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Aged, 80 and over, Cytoreduction Surgical Procedures, Hyperthermia, Induced, Hyperthermic Intraperitoneal Chemotherapy, General Medicine, Combined Modality Therapy, Survival Rate, Percutaneous Coronary Intervention, Antineoplastic Combined Chemotherapy Protocols, Humans, Surgery, Colorectal Neoplasms, Peritoneal Neoplasms, Aged, Retrospective Studies |
| الوصف: | The prevalence of elderly patients with resectable colorectal peritoneal metastases (CRPM) is increasing. This study aimed to compare short and long-term outcomes of cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for CRPM in patients above and below 70 years of age.This was a retrospective, 10-year analysis of 90-day major morbidity and mortality, and long-term survival.Thirty-two (21.3%) of 150 consecutive patients who underwent CRS and HIPEC during the study period were aged 70 and older. PCI (P = 0.04), perioperative chemotherapy use (P 0.01) and organ resections (rectum P = 0.04, diaphragm P = 0.03) were less in the over 70 group. There was no significant differences in major morbidity (P = 0.19) and mortality (P = 0.32). There was also no difference in 5-year overall survival (OS) (≥70: 26% vs.70: 39%; P = 0.68) and disease-free survival (DFS) (≥70: 25% vs.70: 14%; P = 0.22). Age above 70 was not independently associated with worse OS (HR 1.55, P = 0.20) and DFS (HR 1.07, P = 0.81).The surgical management of CRPM appears safe and feasible in this elderly population. Appropriate selection of elderly patients for such radical intervention is reinforced by the comparable survival with those under 70. |
| تدمد: | 1445-2197 1445-1433 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d64eae71ae305889ee54fad5fba2a97bTest https://doi.org/10.1111/ans.17761Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d64eae71ae305889ee54fad5fba2a97b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14452197 14451433 |
|---|