Revisiting human T-cell lymphotropic virus types 1 and 2 infections among rural population in Gabon, central Africa thirty years after the first analysis
| العنوان: | Revisiting human T-cell lymphotropic virus types 1 and 2 infections among rural population in Gabon, central Africa thirty years after the first analysis |
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| المؤلفون: | Guillaume Besson, Cindy Padilla, Maria Makuwa, Mélanie Caron, Eric M. Leroy, Mirdad Kazanji, Dieudonné Nkoghe |
| المساهمون: | Centre International de Recherches Médicales de Franceville (CIRMF), Ministère de la Santé, Ministère de la santé, Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), The ‘Centre International de Recherches Medicales de Franceville’, in Franceville, Gabon, is funded by the Gabonese Government, Total Gabon and the French Foreign Ministry. The ‘Fonds de Solidarite Prioritaire’ of the French Foreign Ministry and the Global Viral Forecasting in San Francisco, USA are the funders., We thank Philippe Yaba, Andre Delicat, Paul Ngari and Philippe Engandja for technical help. |
| المصدر: | PLoS Neglected Tropical Diseases, Vol 12, Iss 10, p e0006833 (2018) PLoS Neglected Tropical Diseases PLoS Neglected Tropical Diseases, Public Library of Science, 2018, 12 (10), pp.e0006833. ⟨10.1371/journal.pntd.0006833⟩ |
| بيانات النشر: | Public Library of Science (PLoS), 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | RNA viruses, Male, Rural Population, 0301 basic medicine, HTLV-1 infection, Epidemiological study, Epidemiology, medicine.medical_treatment, Artificial Gene Amplification and Extension, Pathology and Laboratory Medicine, Antibodies, Viral, Polymerase Chain Reaction, Serology, Geographical Locations, Risk Factors, Seroepidemiologic Studies, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Surveys and Questionnaires, Medicine and Health Sciences, Medicine, Young adult, Phylogeny, Data Management, Aged, 80 and over, Human T-lymphotropic virus 1, Molecular Epidemiology, education.field_of_study, Central Africa, lcsh:Public aspects of medicine, Human T-lymphotropic virus 2, Phylogenetic Analysis, Middle Aged, Medical abortion, 3. Good health, Phylogenetics, Infectious Diseases, Medical Microbiology, Viral Pathogens, Viruses, Pathogens, Research Article, Adult, Computer and Information Sciences, medicine.medical_specialty, lcsh:Arctic medicine. Tropical medicine, Adolescent, lcsh:RC955-962, Blotting, Western, 030106 microbiology, Population, Enzyme-Linked Immunosorbent Assay, Research and Analysis Methods, Microbiology, Young Adult, 03 medical and health sciences, Retroviruses, Animals, Humans, Seroprevalence, Evolutionary Systematics, Gabon, Molecular Biology Techniques, education, Microbial Pathogens, Molecular Biology, Taxonomy, Aged, Evolutionary Biology, Biology and life sciences, Molecular epidemiology, business.industry, Organisms, Public Health, Environmental and Occupational Health, lcsh:RA1-1270, Htlv-1, Sequence Analysis, DNA, HTLV-I Infections, 030104 developmental biology, Medical Risk Factors, People and Places, Africa, HTLV-II Infections, HTLV-1 Infection, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, business, Demography |
| الوصف: | HTLV-1 infection is considered as highly endemic in central Africa. Thirty years ago, a first epidemiological study was performed in Gabon, central Africa, and revealed that the prevalence varied from 5.0 to 10.5%. To evaluate current distribution of HTLVs in Gabon, 4.381 samples were collected from rural population living in 220 villages distributed within the 9 provinces of country. HTLVs prevalence was determined using two ELISA tests and positive results were confirmed by Western Blot. The overall HTLV-1 seroprevalence was of 7.3% among the rural Gabonese population; with 5.4% for men and 9.0% for women. Prevalence of HTLV-1 differed by province, ranging from 2.3% to 12.5% into the rain forest. Being a woman older than 51 years represented a high risk for HTLV-1 acquisition. Hospitalization, operation/surgery, transfusion and medical abortion or fever, arthritis and abdominal pain are also significant risk factors. In addition, 0.1% of samples were found as HTLV-2 positive, while 12.0% had an indeterminate HTLV serological pattern. HTLV-3 and HTLV-4 were not found. Phylogenetic analysis was performed on 87 samples and demonstrated that HTLV-1 present in Gabon belongs mostly to subtype B, however the rare subtype D was also found. Altogether, our results demonstrate that almost thirty years after the first epidemiological study prevention of HTLVs infection is still an issue in Gabon. Author summary HTLV-1 is endemic in Africa where it infects millions of individuals and causes Adult T Leukemia. Thirty years ago, an epidemiological study was performed in Gabon, where HTLV-1 is endemic. This revealed a high prevalence of this retroviral infection. Thirty years later, we performed a larger study in the general Gabonese population. This reveals that this oncogenic retrovirus is still highly frequent in this country and that prevalence remains unchanged. It would be extremely important to inform the general population about this infection in order to be able to decrease this retrovirus transmission. |
| اللغة: | English |
| تدمد: | 1935-2735 1935-2727 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d59b3fe8dce7d3fdf863ba0232cf8fa7Test http://europepmc.org/articles/PMC6201875?pdf=renderTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d59b3fe8dce7d3fdf863ba0232cf8fa7 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19352735 19352727 |
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