Risk factors for incomplete excision of cutaneous squamous cell carcinoma: a large cohort study
| العنوان: | Risk factors for incomplete excision of cutaneous squamous cell carcinoma: a large cohort study |
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| المؤلفون: | N. Marsidi, R. Ottevanger, J.N. Bouwes Bavinck, N.M.A. Krekel ‐ Taminiau, J.J. Goeman, R.E. Genders |
| المصدر: | Journal of the European Academy of Dermatology and Venereology, 36(8), 1229-1234. WILEY |
| بيانات النشر: | Wiley, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Cohort Studies, Skin Neoplasms, Infectious Diseases, Risk Factors, Carcinoma, Squamous Cell, Humans, Dermatology, Neoplasm Recurrence, Local, Neoplasm Staging, Retrospective Studies |
| الوصف: | Background The standard treatment for cutaneous squamous cell carcinoma (cSCC) is surgical excision. Failure to radically remove a cSCC is a risk for recurrence, progression and metastasis. Objectives This study investigates several risk factors for incomplete excision of cSCC. Methods All consecutive patients in a single institution treated with wide local excision for primary cSCC over a 10-year period were included in this study. Risk factors such as: gender, age, immunosuppression, tumour size, location, differentiation grade, tumour depth, perineural and lymphovascular invasion (PNI and LVI) were extracted from the database. Univariable and (if applicable) multivariable logistic regression analysis were used to identify risk factors (P < 0.05). Generalized estimating equations (GEEs) were used for multiple tumours within the same patients. Results A total of 566 patients with 1159 cSCC were identified. Univariable and multivariable logistic regression analysis showed that depth beyond the dermis (OR: 5.7 95% CI: 3.1-10.5) was the only risk factor for incomplete excision of cSCC. Immunosuppression was only a risk factor in the deep plane (OR: 2.5, 95% CI: 1.3-4.6). Conclusion Tumour depth beyond the dermis is the most important risk factor for incomplete excision of cSCC. Immunosuppression is a risk factor in the deep plane but its relevance is uncertain. Immunosuppression is not consistently included in the current cSCC staging systems, but care should be taken when treating these patients. |
| تدمد: | 1468-3083 0926-9959 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d56b987d8c999a63ca079239c1e94bb1Test https://doi.org/10.1111/jdv.18101Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d56b987d8c999a63ca079239c1e94bb1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14683083 09269959 |
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