Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes
| العنوان: | Differential Expression of Cancer Stem Cell Markers ALDH1 and CD133 in Various Lung Cancer Subtypes |
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| المؤلفون: | Ahmad Shariftabrizi, Raheleh Roudi, Alireza Korourian, Zahra Madjd |
| المصدر: | Cancer Investigation. 33:294-302 |
| بيانات النشر: | Informa UK Limited, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Oncology, Cancer Research, medicine.medical_specialty, Lung Neoplasms, Adenocarcinoma, Biology, Stem cell marker, Aldehyde Dehydrogenase 1 Family, Antigens, CD, Cancer stem cell, Carcinoma, Non-Small-Cell Lung, Internal medicine, Biomarkers, Tumor, medicine, Humans, AC133 Antigen, Differential expression, Lung cancer, neoplasms, Aged, Glycoproteins, Aged, 80 and over, Retinal Dehydrogenase, General Medicine, Middle Aged, medicine.disease, Phenotype, respiratory tract diseases, Isoenzymes, carbohydrates (lipids), Tissue Array Analysis, embryonic structures, Neoplastic Stem Cells, Cancer research, Female, Peptides, Large group |
| الوصف: | Cancer stem cells (CSCs) are hypothesized to be the main culprit of lung cancer progression. Clinicopathological significance of stem cell markers CD133 and ALDH1 in a large group of lung cancer patients was evaluated. ALDH1 and CD133 had higher expression levels in the NSCLC compared to the SCLC. Over-expression of both ALDH1 and CD133 markers was exclusively found in SCC and ADC. Low level of ALDH1 expression was strongly correlated with poor differentiation in ADC cases. Thus, ALDH1(high)/CD133(high) phenotype can be considered as a CSC marker in some lung cancer subtypes. |
| تدمد: | 1532-4192 0735-7907 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d50c60f16a32c1afe349a6b4c8b850a3Test https://doi.org/10.3109/07357907.2015.1034869Test |
| رقم الانضمام: | edsair.doi.dedup.....d50c60f16a32c1afe349a6b4c8b850a3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15324192 07357907 |
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