Lack of effect on in-hospital mortality of drugs used during COVID-19 pandemic: Findings of the retrospective multicenter COVOCA study
| العنوان: | Lack of effect on in-hospital mortality of drugs used during COVID-19 pandemic: Findings of the retrospective multicenter COVOCA study |
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| المؤلفون: | Pafundi P. C., Galiero R., Simeon V., Rinaldi L., Perrella A., Vetrano E., Caturano A., Alfano M., Beccia D., Nevola R., Marfella R., Sardu C., Coppola C., Scarano F., Maggi P., de Lucia Sposito P., Vocciante L., Rescigno C., Sbreglia C., Fraganza F., Parrella R., Romano A., Calabria G., Polverino B., Pagano A., Bologna C., Amitrano M., Esposito V., Coppola N., Maturo N., Adinolfi L. E., Chiodini P., Sasso F. C., Bec D., Monari C., de Angelis G., Gaglione G., Parente S., Lumino P., Rossomando A., Catalano M., Paradiso L., Maraolo A., Numis F., Asti A., Langella M., Mangiacapra S., Raimondo M., Del Mastro A., Nasti R., Codella A., Cirillo P. |
| المساهمون: | Pafundi, P. C., Galiero, R., Simeon, V., Rinaldi, L., Perrella, A., Vetrano, E., Caturano, A., Alfano, M., Beccia, D., Nevola, R., Marfella, R., Sardu, C., Coppola, C., Scarano, F., Maggi, P., de Lucia Sposito, P., Vocciante, L., Rescigno, C., Sbreglia, C., Fraganza, F., Parrella, R., Romano, A., Calabria, G., Polverino, B., Pagano, A., Bologna, C., Amitrano, M., Esposito, V., Coppola, N., Maturo, N., Adinolfi, L. E., Chiodini, P., Sasso, F. C., Bec, D., Monari, C., de Angelis, G., Gaglione, G., Parente, S., Lumino, P., Rossomando, A., Catalano, M., Paradiso, L., Maraolo, A., Numis, F., Asti, A., Langella, M., Mangiacapra, S., Raimondo, M., Del Mastro, A., Nasti, R., Codella, A., Cirillo, P. |
| المصدر: | PLoS ONE, Vol 16, Iss 9, p e0256903 (2021) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Viral Diseases, Anticoagulant Therapy, Cancer Treatment, Antiplatelet Therapy, Steroid Therapy, chemistry.chemical_compound, Medical Conditions, Pandemic, Medicine and Health Sciences, Medicine, Public and Occupational Health, Cumulative incidence, Hospital Mortality, Multidisciplinary, Pharmaceutics, Incidence (epidemiology), Middle Aged, Vaccination and Immunization, Oral Antiplatelet Therapy, Cardiovascular Therapy, Infectious Diseases, Oncology, Italy, Female, Research Article, Human, medicine.drug, Cohort study, Respiratory Therapy, medicine.medical_specialty, Corticosteroid Therapy, Science, Immunology, Antiviral Agents, Tocilizumab, Pharmacotherapy, Drug Therapy, Antiviral Therapy, Antibody Therapy, Humans, Pandemics, Aged, Retrospective Studies, Antiviral Agent, business.industry, Biology and Life Sciences, COVID-19, Covid 19, Hydroxychloroquine, Retrospective cohort study, COVID-19 Drug Treatment, chemistry, Emergency medicine, Clinical Immunology, Preventive Medicine, Clinical Medicine, business |
| الوصف: | Introduction During COVID-19 pandemic, the use of several drugs has represented the worldwide clinical practice. However, though the current increase of knowledge about the disease, there is still no effective treatment for the usage of drugs. Thus, we retrospectively assessed use and effects of therapeutic regimens in hospitalized patients on in-hospital mortality. Methods COVOCA is a retrospective observational cohort study on 18 COVID centres throughout Campania Region Hospitals. We included adult patients with confirmed SARS-CoV-2 infection, discharged/dead between March/June 2020. Results 618 patients were included, with an overall in-hospital cumulative mortality incidence of 23.1%. Most prescribed early treatments were antivirals (72%), antibiotics (65%) and hydroxychloroquine/anticoagulants (≈50%). Tocilizumab, indeed, was largely prescribed late during hospitalization. Multivariable models, with a cut-off at day 2 for early COVID-19 therapy administration, did not disclose any significant association of a single drug administration on the clinical outcome. Discussion COVOCA represents the first multicenter database in Campania region. None drug class used during the pandemic significantly modified the outcome, regardless of therapy beginning, both overall and net of those already in non-invasive ventilation (NIV)/ orotracheal intubation (OTI) at hospitalization. Our cumulative incidence of mortality seems lower than other described during the same period, particularly in Northern Italy. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4fcad061b54ce3b9b339b2254e79da1Test https://doaj.org/article/2bef2e26ff134045809a52a76e7e7ffaTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d4fcad061b54ce3b9b339b2254e79da1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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