Association between endothelin-1 and fibromyalgia syndrome
| العنوان: | Association between endothelin-1 and fibromyalgia syndrome |
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| المؤلفون: | Hyung Ki Kim, Hansol Won, S. H. Chang, Jun‑Tack Kwon, Seong Su Nah, Yeongseon Hong, Hak-Jae Kim, Hwa Young Lee, Jiyun Im |
| المصدر: | Molecular Medicine Reports. 16:6234-6239 |
| بيانات النشر: | Spandidos Publications, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, Male, Risk, Cancer Research, medicine.medical_specialty, Fibromyalgia, Genotype, 030204 cardiovascular system & hematology, Polymorphism, Single Nucleotide, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Polymorphism (computer science), Internal medicine, Genetics, medicine, Humans, SNP, Genetic Predisposition to Disease, Allele, Molecular Biology, Alleles, reproductive and urinary physiology, 030203 arthritis & rheumatology, Endothelin-1, business.industry, Case-control study, Endothelial Cells, hemic and immune systems, Vasospasm, Middle Aged, medicine.disease, Endothelin 1, biological factors, Endocrinology, Oncology, Hyperalgesia, Case-Control Studies, embryonic structures, Immunology, Molecular Medicine, Female, medicine.symptom, business |
| الوصف: | Fibromyalgia syndrome (FMS) is characterized by widespread chronic musculoskeletal pain, stiffness and pressure hyperalgesia at soft tissue tender points. Patients with FMS may exhibit a tendency towards cold extremities and cold‑induced vasospasm. Endothelin‑1 (EDN1) is a potent vasoconstrictor that is mainly produced by endothelial cells. The present study aimed to determine whether plasma expression levels avvnd single‑nucleotide polymorphism (SNP; rs1800541) of the EDN1 gene were associated with FMS and/or any of its clinical variables. Plasma EDN1 levels were assessed by ELISA, and SNP genotypes were determined using polymerase chain reaction‑high‑resolution melting curve analysis. Patients with the TG genotype and the G allele may have an elevated risk of FMS. In addition, patients with FMS with the TG genotype and/or T allele exhibited higher plasma EDN1 levels compared with healthy controls. EDN1 levels increased significantly in patients with FMS compared with normal controls. In addition, EDN1 SNP was found to be associated with susceptibility to FMS. |
| تدمد: | 1791-3004 1791-2997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4cbc47860f99f42bc9e66ba1d7af900Test https://doi.org/10.3892/mmr.2017.7395Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d4cbc47860f99f42bc9e66ba1d7af900 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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