Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection
| العنوان: | Toxoplasma gondii effector TgIST blocks type I interferon signaling to promote infection |
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| المؤلفون: | Philipp Olias, Qiuling Wang, Eugene Park, Wayne M. Yokoyama, Zhou Huang, L. David Sibley, Sumit K. Matta |
| المصدر: | Proceedings of the National Academy of Sciences. 116:17480-17491 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Multidisciplinary, biology, Effector, 030106 microbiology, Toxoplasma gondii, Virulence, Biological Sciences, biology.organism_classification, medicine.disease, Toxoplasmosis, Microbiology, 03 medical and health sciences, chemistry.chemical_compound, 030104 developmental biology, chemistry, Interferon, medicine, biology.protein, STAT1, Growth inhibition, Receptor, medicine.drug |
| الوصف: | In contrast to the importance of type II interferon-γ (IFN-γ) in control of toxoplasmosis, the role of type I IFN is less clear. We demonstrate here that TgIST, a secreted effector previously implicated in blocking type II IFN-γ signaling, also blocked IFN-β responses by inhibiting STAT1/STAT2-mediated transcription in infected cells. Consistent with a role for type I IFN in cell intrinsic control, ∆ Tgis t mutants were more susceptible to growth inhibition by murine and human macrophages activated with IFN-β. Additionally, type I IFN was important for production of IFN-γ by natural killer (NK) cells and recruitment of inflammatory monocytes at the site of infection. Mice lacking type I IFN receptors (Ifnar1 −/− ) showed increased mortality following infection with wild-type parasites and decreased virulence of ∆Tgist parasites was restored in Ifnar1 −/− mice. The findings highlight the importance of type I IFN in control of toxoplasmosis and illuminate a parasite mechanism to counteract the effects of both type I and II IFN-mediated host defenses. |
| تدمد: | 1091-6490 0027-8424 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d44f0ac9aa005c793070810a2b614310Test https://doi.org/10.1073/pnas.1904637116Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d44f0ac9aa005c793070810a2b614310 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
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