The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study
| العنوان: | The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study |
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| المؤلفون: | Robert A. McCutcheon, Federico Turkheimer, Sameer Jauhar, Philip McGuire, Maria Rogdaki, Mattia Veronese, Alice Egerton, Mitul M. Mehta, Oliver D. Howes, Matthew M. Nour, Fiona Pepper |
| المصدر: | Biological Psychiatry. Cognitive Neuroscience and Neuroimaging Biological Psychiatry: Cognitive Neuroscience and Neuroimaging |
| بيانات النشر: | Elsevier, Inc, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Psychosis, Cognitive Neuroscience, Dopamine, Striatum, 050105 experimental psychology, 03 medical and health sciences, Functional connectivity, 0302 clinical medicine, Medicine, Humans, 0501 psychology and cognitive sciences, Radiology, Nuclear Medicine and imaging, Resting state, Biological Psychiatry, Default mode network, Negative symptoms, Positive symptoms, Schizophrenia, Resting state fMRI, medicine.diagnostic_test, business.industry, 05 social sciences, Reproducibility of Results, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Corpus Striatum, Archival Report, Psychotic Disorders, Positron emission tomography, Positron-Emission Tomography, Neurology (clinical), business, Neuroscience, 030217 neurology & neurosurgery, medicine.drug |
| الوصف: | Background Striatal dopamine dysfunction is thought to underlie symptoms in psychosis, yet it remains unclear how a single neurotransmitter could cause the diverse presentations that are observed clinically. One hypothesis is that the consequences of aberrant dopamine signaling vary depending on where within the striatum the dysfunction occurs. Positron emission tomography allows for the quantification of dopamine function across the striatum. In the current study, we used a novel method to investigate the relationship between spatial variability in dopamine synthesis capacity and psychotic symptoms. Methods We used a multimodal imaging approach combining 18F-DOPA positron emission tomography and resting-state magnetic resonance imaging in 29 patients with first-episode psychosis and 21 healthy control subjects. In each participant, resting-state functional connectivity maps were used to quantify the functional connectivity of each striatal voxel to well-established cortical networks. Network-specific striatal dopamine synthesis capacity (Kicer) was then calculated for the resulting connectivity-defined parcellations. Results The connectivity-defined parcellations generated Kicer values with equivalent reliability, and significantly greater orthogonality compared with standard anatomical parcellation methods. As a result, dopamine-symptom associations were significantly different from one another for different subdivisions, whereas no unique subdivision relationships were found when using an anatomical parcellation. In particular, dopamine function within striatal areas connected to the default mode network was strongly associated with negative symptoms (p Conclusions These findings suggest that individual differences in the topography of dopamine dysfunction within the striatum contribute to shaping psychotic symptomatology. Further validation of the novel approach in future studies is necessary. |
| اللغة: | English |
| تدمد: | 2451-9030 2451-9022 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3f856b29665e15c75d6a35f8883b54eTest http://europepmc.org/articles/PMC7645803Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d3f856b29665e15c75d6a35f8883b54e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24519030 24519022 |
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