Possible role of the plasminogen activation system in human subfertility
| العنوان: | Possible role of the plasminogen activation system in human subfertility |
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| المؤلفون: | Régine P.M. Steegers-Theunissen, Gerhard A. Zielhuis, Chris M.G. Thomas, Anneke Geurts-Moespot, I.M.W. Ebisch, Fred C.G.J. Sweep |
| المساهمون: | Obstetrics & Gynecology |
| المصدر: | Fertility and Sterility, 87, 619-26 Fertility and Sterility, 87, 3, pp. 619-26 Fertility & Sterility, 87(3), 619-626. Elsevier Inc. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Age-related aspects of cancer [ONCOL 2], Pregnancy Rate, medicine.medical_treatment, Fertilization in Vitro, Aetiology, screening and detection [ONCOL 5], Intracytoplasmic sperm injection, Plasminogen Activators, chemistry.chemical_compound, Pregnancy, Semen, Translational research [ONCOL 3], Internal medicine, Plasminogen Activator Inhibitor 1, medicine, Humans, Outpatient clinic, Sperm Injections, Intracytoplasmic, Progesterone, Gynecology, Estradiol, Endocrinology and reproduction [UMCN 5.2], T-plasminogen activator, business.industry, Hormonal regulation [IGMD 6], Obstetrics and Gynecology, Spermatozoa, Urokinase-Type Plasminogen Activator, Follicular fluid, Follicular Fluid, Human Reproduction [NCEBP 12], Pregnancy rate, Endocrinology, Reproductive Medicine, chemistry, Evaluation of complex medical interventions [NCEBP 2], Case-Control Studies, Infertility, Tissue Plasminogen Activator, Plasminogen activator inhibitor-1, Female, Geometric mean, business, Plasminogen activator |
| الوصف: | Contains fulltext : 52549.pdf (Publisher’s version ) (Closed access) OBJECTIVE: To correlate components of the plasminogen activator (PA) system with fertility outcome parameters in participants in an IVF/intracytoplasmic sperm injection (ICSI) procedure. DESIGN: Case-control study. SETTING: Outpatient clinic for IVF/ICSI treatment at the Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands. PATIENT(S): One hundred and fifty-six couples undergoing an IVF/ICSI procedure. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA), plasminogen activator inhibitor 1 (PAI-1), and t-PA-PAI-1 complex concentrations in the ejaculate, spermatozoa, and follicular fluid (FF). RESULT(S): Concentrations of t-PA were higher in spermatozoa of the male factor subfertility group (geometrical mean, 77.1 pg/million spermatozoa; 25th-75th percentiles, 31.8-211.2), compared to fertile men (geometrical mean, 1.91; 25th-75th percentiles, 0.74-5.79) and idiopathic subfertile men (geometrical mean, 3.14; 25th-75th percentiles, 0.97-9.97). Furthermore, the concentration of t-PA in spermatozoa was significantly associated with pregnancy (odds ratio [OR], 0.995). Likewise, a trend was shown for higher t-PA concentrations in the FF of women with fallopian-tube pathology (geometrical mean, 18.5 pg t-PA/mg protein; 25th-75th percentiles, 11.4-25.7) or endometriosis (geometrical mean, 18.8; 25th-75th percentiles, 11.4-27.1), compared to fertile women (geometrical mean, 14.3; 25th-75th percentiles, 10.3-17.6) and idiopathic subfertile women (geometrical mean, 13.9; 25th-75th percentiles, 9.5-17.8). Also, t-PA in FF is associated with the proportion of cleaved embryos (regression coefficient, 0.16). The concentrations of u-PA, PAI-1, and t-PA-PAI-1 complex were comparable between diagnostic subgroups in both men and women. CONCLUSION(S): The t-PA concentrations in spermatozoa and FF tend to be higher in human subfertility, and seem to be associated with some fertility outcome parameters. |
| وصف الملف: | application/pdf |
| تدمد: | 0015-0282 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d37b6261ba21b898638c0059fba58ce0Test https://hdl.handle.net/2066/52549Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....d37b6261ba21b898638c0059fba58ce0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00150282 |
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