The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial
| العنوان: | The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides: a randomized trial |
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| المؤلفون: | Mads J. Skytte, Thure Krarup, Carolyn F. Deacon, Christian Anholm, Arne Astrup, Sten Madsbad, Amirsalar Samkani, Raymond C. Boston, Steen B. Haugaard, Jens J. Holst |
| المصدر: | Samkani, A, Skytte, M G J, Anholm, C, Astrup, A, Deacon, C F, Holst, J J, Madsbad, S, Boston, R, Krarup, T & Haugaard, S B 2018, ' The acute effects of dietary carbohydrate reduction on postprandial responses of non-esterified fatty acids and triglycerides : a randomized trial ', Lipids in Health and Disease, vol. 17, 295 . https://doi.org/10.1186/s12944-018-0953-8Test Lipids in Health and Disease, Vol 17, Iss 1, Pp 1-9 (2018) Lipids in Health and Disease |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Clinical Biochemistry, Short Report, 030209 endocrinology & metabolism, Clinical nutrition, Fatty Acids, Nonesterified, 030204 cardiovascular system & hematology, Diet, Carbohydrate-Restricted, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Endocrinology, NEFA, Internal medicine, Diabetes mellitus, Faculty of Science, Humans, Medicine, lcsh:RC620-627, Triglycerides, Aged, Meal, Cross-Over Studies, Triglyceride, business.industry, Insulin, digestive, oral, and skin physiology, Biochemistry (medical), Middle Aged, Postprandial Period, medicine.disease, lcsh:Nutritional diseases. Deficiency diseases, Postprandial, Diabetes Mellitus, Type 2, chemistry, Female, Non-esterified fatty acids, business, Postprandial triglycerides, Dietary carbohydrate reduction, Lipidology |
| الوصف: | Background: Postprandial non-esterified fatty acid (NEFA) and triglyceride (TG) responses are increased in subjects with type 2 diabetes mellitus (T2DM) and may impair insulin action and increase risk of cardiovascular disease and death. Dietary carbohydrate reduction has been suggested as non-pharmacological therapy for T2DM, but the acute effects on NEFA and TG during subsequent meals remain to be investigated.Methods: Postprandial NEFA and TG responses were assessed in subjects with T2DM by comparing a carbohydrate-reduced high-protein (CRHP) diet with a conventional diabetes (CD) diet in an open-label, randomized, cross-over study. Each diet was consumed on two consecutive days, separated by a wash-out period. The iso-caloric CRHP/CD diets contained 31/54 E% from carbohydrate, 29/16 E% energy from protein and 40/30 E% from fat, respectively. Sixteen subjects with well-controlled T2DM (median HbA1c 47 mmol/mol, (37-67 mmol/mol) and BMI 30 ± 4.4 kg/m2) participated in the study. NEFA and TG were evaluated following breakfast and lunch.Results: NEFA net area under curve (AUC) was increased by 97 ± 38 μmol/Lx270 min (p = 0.024) after breakfast but reduced by 141 ± 33 μmol/Lx180 min (p p = 0.012) after breakfast but reduced by 320 ± 60 μmol/Lx180 min (p Conclusions: In well-controlled T2DM a modest reduction of dietary carbohydrate with a corresponding increase in protein and fat acutely reduced postprandial serum NEFA suppression and increased serum TG responses after a breakfast meal but had the opposite effect after a lunch meal. The mechanism behind this second-meal phenomenon of CRHP diet on important risk factors for aggravating T2DM and cardiovascular disease awaits further investigation.Trial registration: The study was registered at clinicaltrials.gov ID: NCT02472951. https://clinicaltrials.gov/ct2/show/NCT02472951Test . Registered June 16, 2015. |
| وصف الملف: | application/pdf |
| تدمد: | 1476-511X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d3755fd18a6894a513e094ea876e5532Test https://doi.org/10.1186/s12944-018-0953-8Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d3755fd18a6894a513e094ea876e5532 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1476511X |
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