Daptomycin versus vancomycin as post-operative empirical antibiotic treatment for prosthetic joint infections: a case-control study
| العنوان: | Daptomycin versus vancomycin as post-operative empirical antibiotic treatment for prosthetic joint infections: a case-control study |
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| المؤلفون: | C. Joseph, O. Robineau, M. Titecat, S. Putman, N. Blondiaux, C. Loiez, M. Valette, J. Schmit, E. Beltrand, H. Dézeque, S. Nguyen, H. Migaud, E. Senneville |
| المساهمون: | CHU Amiens-Picardie, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Lille Inflammation Research International Center - U 995 (LIRIC), Institut Pasteur de Lille, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Gustave Dron [Tourcoing], Institut de Microbiologie [CHRU Lille], Pôle de Biologie Pathologie Génétique [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 (MABLab (ex-pmoi)), Université du Littoral Côte d'Opale (ULCO)-Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Inserm, Univ. Littoral Côte d’Opale, Université de Lille, Evaluation des technologies de santé et des pratiques médicales - ULR 2694 [METRICS], Lille Inflammation Research International Center - U 995 [LIRIC], Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille], Marrow Adiposity & Bone Lab - Adiposité Médullaire et Os - ULR 4490 [MABLab (ex-pmoi)] |
| المصدر: | Journal of Bone and Joint Infection Journal of Bone and Joint Infection, Copernicus Publications, 2019, 4 (2), pp.72-75. ⟨10.7150/jbji.22118⟩ Journal of Bone and Joint Infection, Vol 4, Pp 72-75 (2019) Journal of Bone and Joint Infection, 2019, 4 (2), pp.72-75. ⟨10.7150/jbji.22118⟩ |
| بيانات النشر: | HAL CCSD, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Short Research Paper, medicine.medical_specialty, Cefotaxime, Daptomycin, Vancomycin, empirical antibiotic treatment, prosthetic joint infection, Cefepime, medicine.medical_treatment, [SDV]Life Sciences [q-bio], 030106 microbiology, Periprosthetic, Prosthesis, 03 medical and health sciences, 0302 clinical medicine, lcsh:Orthopedic surgery, Internal medicine, medicine, Orthopedics and Sports Medicine, 030212 general & internal medicine, Adverse effect, business.industry, 3. Good health, Discontinuation, lcsh:RD701-811, Infectious Diseases, Surgery, business, medicine.drug |
| الوصف: | Purpose: To compare safety and efficacy of Vancomycin (Van) versus Daptomycin (Dap) as post-operative empirical antibiotic treatment (PEAT) in patients with periprosthetic joint infections (PJIs).Methods: Medical charts of patients treated empirically with Van or Dap in the post-operative period of total hip/knee prosthesis septic revision until the results of intra-operative culture were reviewed. Cefotaxime, cefepime or aztreonam were used in combination with Dap or Van.Results: Twenty Dap patients were matched with 20 other Van patients according to the age and type of prosthesis. The ASA score and the distribution of the pathogens was similar in the two groups especially regarding the number of methicillin-resistant staphylococci. The mean duration of the PEAT was 6.07 ± 0.85 days. A total of 17 episodes of adverse events (AE) in 10 patients (25%) were recorded during the PEAT which led to discontinue the treatment in 5 patients, all of them treated with Van (P=0.02). At the end of a mean post-treatment follow-up of 618 +/- 219 days, 36 patients remained in remission of infection; 2 patients failed in each group.Conclusions: Our observations suggest that PEAT with Van for septic revision of PJIs is associated with a higher discontinuation rate due to AE but with a similar outcome than it is with Dap. |
| وصف الملف: | application/octet-stream; application/rdf+xml; charset=utf-8; application/pdf |
| اللغة: | English |
| تدمد: | 2206-3552 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31e82b1c169ee50ae126d889d1028b6Test https://hal.univ-lille.fr/hal-02573124/file/v04p0072.pdfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d31e82b1c169ee50ae126d889d1028b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22063552 |
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