Correction: Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes
| العنوان: | Correction: Rapid Progressing Allele HLA-B35 Px Restricted Anti-HIV-1 CD8+ T Cells Recognize Vestigial CTL Epitopes |
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| المؤلفون: | Christian B. Willberg, Keith E. Garrison, R. Brad Jones, Duncan A. Meiklejohn, Gerald Spotts, Teri J. Liegler, Mario A. Ostrowski, Annika C. Karlsson, Frederick M. Hecht, Douglas F. Nixon |
| المصدر: | PloS one, vol 11, iss 7 PLoS ONE PLoS ONE, Vol 11, Iss 7, p e0160293 (2016) |
| بيانات النشر: | eScholarship, University of California, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | General Science & Technology, lcsh:Medicine, Epitopes, T-Lymphocyte, HIV Infections, T-Cell Antigen Receptor Specificity, CD8-Positive T-Lymphocytes, Immunology/Immunity to Infections, Humans, Longitudinal Studies, lcsh:Science, Alleles, Multidisciplinary, lcsh:R, Correction, Genetic Variation, Infectious Diseases/HIV Infection and AIDS, Viral Load, CD4 Lymphocyte Count, Immunology/Immune Response, Disease Progression, HIV-1, lcsh:Q, HLA-B35 Antigen, Immunology/Genetics of the Immune System, Research Article, T-Lymphocytes, Cytotoxic |
| الوصف: | Background The HLA-B*35-Px allele has been associated with rapid disease progression in HIV-1 infection, in contrast to the HLA-B*35-Py allele. Methodology/Principal Findings Immune responses to two HLA-B*35 restricted HIV-1 specific CTL epitopes and their variants were followed longitudinally during early HIV-1 infection in 16 HLA-B*35+ individuals. Subjects expressing HLA-B*35-Px alleles showed no difference in response to the consensus epitopes compared to individuals with HLA-B*35-Py alleles. Surprisingly, all the HLA-B*35-Px+ individuals responded to epitope-variants even in the absence of a consensus response. Sequencing of the viral population revealed no evidence of variant virus in any of the individuals. Conclusions/Significance This demonstrates a novel phenomenon that distinguishes individuals with the HLA-B*35-Px rapid progressing allele and those with the HLA-B*35-Py slower progressing allele. |
| وصف الملف: | application/pdf |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2c4b8835b3eaba7e537f91a1cf2a6d1Test https://escholarship.org/uc/item/99p2x3chTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d2c4b8835b3eaba7e537f91a1cf2a6d1 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |