A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems
| العنوان: | A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems |
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| المؤلفون: | Dorret I. Boomsma, Erik A. Ehli, Xiangjun Xiao, James J. Hudziak, Meike Bartels, Catharina E. M. van Beijsterveldt, Eco J. C. de Geus, Maria M. Groen-Blokhuis, Gareth E. Davies, Robert R. Althoff, Christel M. Middeldorp, Paul Scheet, Sanja Franić |
| المساهمون: | Biological Psychology, Neuroscience Campus Amsterdam - Neurobiology of Mental Health, Neuroscience Campus Amsterdam - Brain Mechanisms in Health & Disease, Child Psychiatry |
| المصدر: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162(5), 457-465. Wiley-Liss Inc. American journal of medical genetics. Part B, Neuropsychiatric genetics, 162(5), 457-465. Wiley-Liss Inc. Groen-Blokhuis, M M, Franic, S, van Beijsterveldt, C E M, de Geus, E J C, Bartels, M, Davies, G E, Ehli, E A, Xiao, X, Scheet, P, Althoff, R R, Hudziak, J J, Middeldorp, C M & Boomsma, D I 2013, ' A prospective study of the effects of breastfeeding and FADS2 polymorphisms on cognition and hyperactivity/attention problems ', American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, vol. 162, no. 5, pp. 457-465 . https://doi.org/10.1002/ajmg.b.32175Test American Journal of Medical Genetics Part B: Neuropsychiatric Genetics |
| سنة النشر: | 2013 |
| مصطلحات موضوعية: | Adult, Fatty Acid Desaturases, Netherlands Twin Register (NTR), FADS2, Breastfeeding, Single-nucleotide polymorphism, Polymorphism, Single Nucleotide, Structural equation modeling, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, SDG 3 - Good Health and Well-being, Humans, Medicine, Prospective Studies, 030212 general & internal medicine, Cognitive skill, Prospective cohort study, Genetics (clinical), business.industry, Infant, Newborn, Infant, Cognition, Educational attainment, Psychiatry and Mental health, Breast Feeding, Attention Deficit Disorder with Hyperactivity, Twin Studies as Topic, Female, Cognition Disorders, business, 030217 neurology & neurosurgery, Clinical psychology |
| الوصف: | Breastfeeding has been associated with improved cognitive functioning. There is a beneficial effect on IQ, and possibly on associated phenotypes such as attention problems. It has been suggested that the effect on IQ is moderated by polymorphisms in the FADS2 gene, which is involved in fatty acid metabolism. In this study we tested the relation between breastfeeding and FADS2 polymorphisms on the one hand and IQ, educational attainment, overactivity, and attention problems on the other hand. IQ at age 5, 7, 10, 12, and/or 18 (n = 1,313), educational attainment at age 12 (n = 1,857), overactive behavior at age 3 (n = 2,560), and attention problems assessed at age 7, 10, and 12 years (n = 2,479, n = 2,423, n = 2,226) were predicted by breastfeeding and two SNPs in FADS2 (rs174575 and rs1535). Analyses were performed using structural equation modeling. After correction for maternal education, a main effect of breastfeeding was found for educational attainment at age 12 and overactive behavior at age 3. For IQ, the effect of breastfeeding across age was marginally significant (P = 0.05) and amounted to 1.6 points after correcting for maternal education. Neither a main effect of the FADS2 polymorphisms nor an interaction with breastfeeding was detected for any of the phenotypes. This developmentally informed study confirms that breastfeeding is associated with higher educational attainment at age 12, less overactive behavior at age 3 and a trend toward higher IQ after correction for maternal education. In general, the benefits of breastfeeding were small and did not interact with SNPs in FADS2. © 2013 Wiley Periodicals, Inc. |
| اللغة: | English |
| تدمد: | 1552-4841 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2961f71e6947ace036c4cd562d40808Test https://doi.org/10.1002/ajmg.b.32175Test |
| حقوق: | RESTRICTED |
| رقم الانضمام: | edsair.doi.dedup.....d2961f71e6947ace036c4cd562d40808 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15524841 |
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