Repair genes expression profile of MLH1, MSH2 and ATM in the normal oral mucosa of chronic smokers
| العنوان: | Repair genes expression profile of MLH1, MSH2 and ATM in the normal oral mucosa of chronic smokers |
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| المؤلفون: | Janete Dias Almeida, Fábio Daumas Nunes, Jaqueline Scholz Issa, Celina Faig Lima Carta, Mônica Ghislaine Oliveira Alves, Patrícia Pimentel de Barros |
| المساهمون: | Universidade Estadual Paulista (Unesp), Universidade Braz Cubas, Universidade de São Paulo (USP) |
| المصدر: | Scopus Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP |
| بيانات النشر: | Elsevier BV, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Adult, 0301 basic medicine, congenital, hereditary, and neonatal diseases and abnormalities, medicine.medical_specialty, Pathology, DNA Repair, DNA repair, Immunocytochemistry, Down-Regulation, Gene Expression, Ataxia Telangiectasia Mutated Proteins, Biology, MLH1, Gene expression immunocytochemistry, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Gene expression, medicine, Carcinoma, Humans, neoplasms, General Dentistry, Gene, Aged, Aged, 80 and over, Squamous cell, Smoking, Mouth Mucosa, nutritional and metabolic diseases, Cell Biology, General Medicine, Middle Aged, medicine.disease, Immunohistochemistry, digestive system diseases, MutS Homolog 2 Protein, 030104 developmental biology, Otorhinolaryngology, MSH2, 030220 oncology & carcinogenesis, MutL Protein Homolog 1 |
| الوصف: | Made available in DSpace on 2018-12-11T17:23:12Z (GMT). No. of bitstreams: 0 Previous issue date: 2017-01-01 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Objective The aim of this study was to evaluate the effect of chronic smoking on the expression profile of the repair genes MLH1, MSH2 and ATM in the normal oral mucosa of chronic smokers and never smokers. Materials and methods The sample consisted of thirty exfoliative cytology smears per group obtained from Smokers and Never Smokers. Total RNA was extracted and expression of the MLH1, MSH2 and ATM genes were evaluated by quantitative real-time and immunocytochemistry. The gene and protein expression data were correlated to the clinical data. Gene expression was analyzed statistically using the Student t-test and Pearson's correlation coefficient, with p |
| تدمد: | 0003-9969 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d265f8b871b80f6e78482a20ee1cd1c6Test https://doi.org/10.1016/j.archoralbio.2016.09.006Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d265f8b871b80f6e78482a20ee1cd1c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 00039969 |
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