Chaperoning RPA during DNA metabolism
| العنوان: | Chaperoning RPA during DNA metabolism |
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| المؤلفون: | Shuangshuang Yang, Qing Li, Jianxun Feng, Shuqi Li, Ziqi Dong |
| المصدر: | Current Genetics. 65:857-864 |
| بيانات النشر: | Springer Science and Business Media LLC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | DNA Replication, Saccharomyces cerevisiae Proteins, DNA Repair, genetic processes, Saccharomyces cerevisiae, Regulator, DNA, Single-Stranded, Proteomics, complex mixtures, Genomic Instability, 03 medical and health sciences, chemistry.chemical_compound, Replication Protein A, Genetics, Humans, Replication protein A, Protein secondary structure, 030304 developmental biology, Recombination, Genetic, 0303 health sciences, biology, 030302 biochemistry & molecular biology, DNA replication, RNA-Binding Proteins, DNA, General Medicine, biology.organism_classification, Cell biology, enzymes and coenzymes (carbohydrates), chemistry, Chaperone (protein), health occupations, biology.protein, Molecular Chaperones |
| الوصف: | Single-stranded DNA (ssDNA) is widely generated during DNA metabolisms including DNA replication, repair and recombination and is susceptible to digestion by nucleases and secondary structure formation. It is vital for DNA metabolism and genome stability that ssDNA is protected and stabilized, which are performed by the major ssDNA-binding protein, and replication protein A (RPA) in these processes. In addition, RPA-coated ssDNA also serves as a protein-protein-binding platform for coordinating multiple events during DNA metabolisms. However, little is known about whether and how the formation of RPA-ssDNA platform is regulated. Here we highlight our recent study of a novel RPA-binding protein, Regulator of Ty1 transposition 105 (Rtt105) in Saccharomyces cerevisiae, which regulates the RPA-ssDNA platform assembly at replication forks. We propose that Rtt105 functions as an "RPA chaperone" during DNA replication, likely also promoting the assembly of RPA-ssDNA platform in other processes in which RPA plays a critical role. |
| تدمد: | 1432-0983 0172-8083 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d24da2fc931c3017195859a44d3fe117Test https://doi.org/10.1007/s00294-019-00945-3Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d24da2fc931c3017195859a44d3fe117 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14320983 01728083 |
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