Improving Proteinuria, Endothelial Functions and Asymmetric Dimethylarginine Levels in Chronic Kidney Disease: Ramipril versus Valsartan
| العنوان: | Improving Proteinuria, Endothelial Functions and Asymmetric Dimethylarginine Levels in Chronic Kidney Disease: Ramipril versus Valsartan |
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| المؤلفون: | Yusuf Oguz, Mahmut Ilker Yilmaz, Mutlu Saglam, Erdinc Cakir, Mujdat Yenicesu, Abdulgaffar Vural, Tayfun Eyileten, Mustafa Tasar, Alper Sonmez, Kayser Caglar, Yasemin Gulcan Kurt, Cengizhan Acikel |
| المصدر: | Blood Purification. 25:327-335 |
| بيانات النشر: | S. Karger AG, 2007. |
| سنة النشر: | 2007 |
| مصطلحات موضوعية: | Adult, Blood Glucose, Male, Ramipril, medicine.medical_specialty, Urology, Tetrazoles, Angiotensin-Converting Enzyme Inhibitors, Arginine, urologic and male genital diseases, Renin-Angiotensin System, chemistry.chemical_compound, Internal medicine, medicine, Humans, Endothelial dysfunction, Proteinuria, Chemistry, Valine, Hematology, General Medicine, Middle Aged, medicine.disease, Lipids, Angiotensin II, female genital diseases and pregnancy complications, Vasodilation, C-Reactive Protein, Endocrinology, Valsartan, Nephrology, Hemorheology, ACE inhibitor, Kidney Failure, Chronic, Female, Insulin Resistance, medicine.symptom, Asymmetric dimethylarginine, Angiotensin II Type 1 Receptor Blockers, Biomarkers, Glomerular Filtration Rate, medicine.drug, Kidney disease |
| الوصف: | Background: The aim of this study was to find out whether the beneficial effects of the renin-angiotensin-aldosterone system (RAS) blockage in chronic kidney disease (CKD) has any relation with the alteration of asymmetric dimethylarginine (ADMA) levels. Methods: Sixty-six nondiabetic patients with CKD and proteinuria and 36 healthy subjects were enrolled. Patients were treated with either ramipril 5 mg daily or valsartan 160 mg daily for 3 months. Proteinuria, ADMA, symmetric dimethyl arginine (SDMA), flow-mediated dilatation (FMD) and HOMA index measurements were performed both before and after the treatment. Results: ADMA, SDMA, hsCRP levels, HOMA index and proteinuria of patients were significantly higher (p < 0.001 for all) and FMD, L-arginine and L-arginine/ADMA ratio in CKD were significantly lower than controls. According to the multiple regression analysis, proteinuria levels were independently related to ADMA and SDMA levels. Conclusion: Both drugs were equally effective in reducing elevated ADMA levels and improving endothelial dysfunction in CKD patients. |
| تدمد: | 1421-9735 0253-5068 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d20bbb363c1dcb63d13180647ffb9e37Test https://doi.org/10.1159/000107410Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d20bbb363c1dcb63d13180647ffb9e37 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14219735 02535068 |
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