Prognostic significance of hypoxia inducible factor-1α expression in patients with clear cell renal cell carcinoma
| العنوان: | Prognostic significance of hypoxia inducible factor-1α expression in patients with clear cell renal cell carcinoma |
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| المؤلفون: | Shuiqing Wu, Yinhuai Wang, Zhaohui Zhong, Ran Xu, Fen Jiang, Qiong Lu, Jian Cao, Xuan Zhu, Hongtao Wu, Xiaokun Zhao |
| المصدر: | Molecular Medicine Reports. |
| بيانات النشر: | Spandidos Publications, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Cancer Research, medicine.medical_specialty, Prognostic variable, Kaplan-Meier Estimate, Biochemistry, Gastroenterology, Disease-Free Survival, Hemoglobins, Pulmonary Disease, Chronic Obstructive, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Internal medicine, Genetics, Carcinoma, medicine, Humans, Progression-free survival, Carcinoma, Renal Cell, Molecular Biology, Survival analysis, Aged, Neoplasm Staging, Aged, 80 and over, COPD, business.industry, Middle Aged, Hypoxia (medical), Hypoxia-Inducible Factor 1, alpha Subunit, Prognosis, medicine.disease, Immunohistochemistry, Kidney Neoplasms, Clear cell renal cell carcinoma, 030104 developmental biology, Oncology, 030220 oncology & carcinogenesis, Concomitant, Molecular Medicine, Female, medicine.symptom, business |
| الوصف: | The prognostic significance of hypoxia inducible factor-1α (HIF-1α) expression in tumors and the levels of preoperative hemoglobin in clear cell renal cell carcinoma (ccRCC), with or without concomitant chronic obstructive pulmonary disease (COPD), was investigated. A total of 128 patients with ccRCC who underwent surgery were analyzed using retrospective methods. Overall survival (OS) and progression free survival (PFS) were analyzed with clinicopathological variables, including preoperative hemoglobin levels, COPD and the levels of HIF‑1α expression, by Kaplan‑Meier survival analysis. Levels of HIF‑1α expression were detected by immunohistochemistry and the multivariate analysis was performed by proportional hazards regression. High levels of HIF‑1α expression were associated with a higher pathological stage and histological grade in patients with ccRCC (P |
| تدمد: | 1791-3004 1791-2997 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1cbf0bafcd48590d9af6f05f50dbf38Test https://doi.org/10.3892/mmr.2018.8409Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d1cbf0bafcd48590d9af6f05f50dbf38 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17913004 17912997 |
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