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Clinical and Imaging Markers Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke

التفاصيل البيبلوغرافية
العنوان: Clinical and Imaging Markers Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke
المؤلفون: Kranendonk, K.R. van, Treumiet, K.M., Boers, A.M.M., Berkhemer, O.A., Berg, L.A. van den, Chalos, V., Lingsma, H.F., Zwam, W.H. van, Lugt, A. van der, Oostenbrugge, R.J. van, Dippel, D.W.J., Roos, Y.B.W.E.M., Marquering, H.A., Majoie, C.B.L.M., Fransen, P.S.S., Beumer, D., Yoo, A.J., Schonewille, W.J., Vos, J.A., Nederkoorn, P.J., Wenner, M.J.H., Walderveen, M.A.A. van, Staals, J., Hofmeijer, J., Oostayen, J.A. van, Nijeholt, G.J.L.A., Boiten, J., Brouwer, P.A., Emmet, B.J., Bruijn, S.F. de, Dijk, L.C. van, Kappelle, L.J., R.H. lo, Dijk, E.J. van, Vries, J. de, Kort, P.L.M. de, Rooij, W.J.J. van, Berg, J.S.P. van den, Hassell, B.A.A.M. van, Aerden, L.A.M., Dallinga, R.J., Visser, M.C., Bot, J.C.J., Vroomen, P.C., Eshghi, O., Schreuder, T.H.C.M.L., Heijboer, R.J.J., Keizer, K., Tielbeek, A.V., Hertog, H.M. den, Gerrits, D.G., Berg-Vos, R.M. van den, Karas, G.B., Steyerberg, E.W., Flach, H.Z., Sprengers, M.E.S., Jenniskens, S.F.M., Beenen, L.F.M., Berg, R. van den, Koudstaal, P.J., MR CLEAN Investigators
المساهمون: RS: Carim - B05 Cerebral small vessel disease, RS: CARIM - R3.03 - Cerebral small vessel disease, RS: Carim - B06 Imaging, Beeldvorming, MUMC+: DA BV Medisch Specialisten Radiologie (9), RS: CARIM - R3.11 - Imaging, MUMC+: MA Neurologie (3), Klinische Neurowetenschappen, MUMC+: MA AIOS Neurologie (9), MUMC+: MA Med Staf Spec Neurologie (9), Graduate School, Radiology and Nuclear Medicine, ACS - Atherosclerosis & ischemic syndromes, ACS - Microcirculation, ANS - Neurovascular Disorders, Neurology, Radiology and nuclear medicine, VU University medical center, Amsterdam Neuroscience - Neurovascular Disorders, Radiology & Nuclear Medicine, Orthopedics and Sports Medicine, Public Health
المصدر: Stroke
Stroke, 50(8), 2037-2043. LIPPINCOTT WILLIAMS & WILKINS
Stroke, 50, 8, pp. 2037-2043
Stroke, 50(8), 2037-2043
Stroke; a journal of cerebral circulation, 50(8), 2037-2043. Lippincott Williams and Wilkins
Stroke, 50, 2037-2043
Stroke, 50(8), 2037-2043. Lippincott Williams and Wilkins
MR CLEAN Registry Investigators 2019, ' Clinical and Imaging Markers Associated With Hemorrhagic Transformation in Patients With Acute Ischemic Stroke ', Stroke, vol. 50, no. 8, pp. 2037-2043 . https://doi.org/10.1161/STROKEAHA.118.024255Test
Stroke, 50(8), 2037-2043. Lippincot, Williams & Wilkins
Journal of the American Heart Association, 50(8), 2037-2043. Wiley
سنة النشر: 2019
مصطلحات موضوعية: medicine.medical_specialty, Population, infarction, intracranial hemorrhages, Infarction, BLOOD-PRESSURE, Tissue plasminogen activator, All institutes and research themes of the Radboud University Medical Center, Hematoma, Internal medicine, medicine, risk factors, atrial fibrillation, education, Stroke, TISSUE-PLASMINOGEN ACTIVATOR, Advanced and Specialized Nursing, HEALTH-CARE PROFESSIONALS, education.field_of_study, business.industry, INTRAVENOUS ALTEPLASE, Other Research Radboud Institute for Health Sciences [Radboudumc 0], blood pressure, Atrial fibrillation, SYMPTOMATIC INTRACRANIAL HEMORRHAGE, Odds ratio, Disorders of movement Donders Center for Medical Neuroscience [Radboudumc 3], medicine.disease, stroke, n/a OA procedure, reperfusion, Blood pressure, THROMBOLYTIC THERAPY, ENDOVASCULAR TREATMENT, Cardiology, RISK-FACTORS, TRIAL, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, medicine.drug, INTRAARTERIAL TREATMENT
الوصف: Background and Purpose— Hemorrhagic transformation (HT) after acute ischemic stroke may cause severe neurological deterioration and affects functional outcome. Identifying patients most likely to suffer from this complication could potentially be used for future treatment selection. Reperfusion after endovascular therapy could be associated with different risk factors for HT than intravenous thrombolytics as these treatments largely differ. In this study, we aimed to identify clinical and imaging markers that are associated with HT subtypes in the MR CLEAN (Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands) population. Methods— In this post hoc analysis, all patients with follow-up imaging were included. HT was classified according to ECASS II (European Cooperative Acute Stroke Study). Variables with an association of P Results— Of the 478 out of 500 included patients in this subanalysis, 46% had HT (n=222). Of these, 66% had hemorrhagic infarction (n=147) and 34% PH (n=75). Symptomatic intracranial hemorrhage was observed in 7.3% (n=35) of all patients. Baseline National Institutes of Health Stroke Scale (odds ratio [OR], 1.05,95% CI, 1.01–1.09 per point) and absent/poor collaterals (OR, 1.90; 95% CI, 1.05–3.42) were significantly associated with hemorrhagic infarction. Increased systolic blood pressure (OR, 1.17; 95% CI, 1.05–1.31 per 10 mm Hg) and atrial fibrillation (OR, 1.94; 95% CI, 1.08–3.48) were associated with PH. Increased systolic blood pressure (OR, 1.28; 95% CI, 1.12–1.48) and antiplatelet use (OR, 2.6; 95% CI, 1.08–6.3) were associated with symptomatic intracranial hemorrhage. Conclusions— Clinical and imaging stroke severity parameters were associated with HT, both in hemorrhagic infarction and PH, whereas baseline patients characteristics like systolic blood pressure, atrial fibrillation, and antiplatelet use were only associated with PH or symptomatic intracranial hemorrhage. Clinical Trial Registration— URL: http://www.controlled-trials.comTest . Unique identifier: ISRCTN10888758.
وصف الملف: application/pdf
اللغة: English
تدمد: 0039-2499
2037-2043
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1c9da5cb764330d1b8ff46b2be2db76Test
https://doi.org/10.1161/strokeaha.118.024255Test
حقوق: OPEN
رقم الانضمام: edsair.doi.dedup.....d1c9da5cb764330d1b8ff46b2be2db76
قاعدة البيانات: OpenAIRE
الوصف
تدمد:00392499
20372043