Hypersensitive C-reactive protein-albumin ratio predicts symptomatic intracranial hemorrhage after endovascular therapy in acute ischemic stroke patients
| العنوان: | Hypersensitive C-reactive protein-albumin ratio predicts symptomatic intracranial hemorrhage after endovascular therapy in acute ischemic stroke patients |
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| المؤلفون: | Ying-Dong Zhang, Jian-Kang Hou, Meng Wang, Junshan Zhou, Ting Huang, Nihong Chen, Wei Wang, Feng Zhou, Shi Huang, Si-Yu Wang, Qiang Peng, Yan E |
| المصدر: | BMC Neurology, Vol 21, Iss 1, Pp 1-8 (2021) BMC Neurology |
| بيانات النشر: | BMC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Acute ischemic stroke, Endovascular therapy, Infarction, lcsh:RC346-429, Risk Factors, Internal medicine, medicine, Humans, Symptomatic intracranial hemorrhage, cardiovascular diseases, Risk factor, Serum Albumin, lcsh:Neurology. Diseases of the nervous system, Aged, Ischemic Stroke, biology, Receiver operating characteristic, business.industry, Endovascular Procedures, C-reactive protein, General Medicine, Odds ratio, Middle Aged, Nomogram, medicine.disease, Confidence interval, Nomograms, C-Reactive Protein, Hypersensitive C-reactive protein-albumin ratio, biology.protein, Cardiology, Female, Neurology (clinical), Neurosurgery, business, Intracranial Hemorrhages, Biomarkers, Research Article |
| الوصف: | BackgroundApproximately 10% of patients would develop symptomatic intracranial hemorrhage (sICH) after endovascular therapy. The aim of our study was to explore the ability of hypersensitive C-reactive protein-albumin ratio (HAR) in predicting sICH after endovascular therapy.MethodsFrom April 2016 to December 2018, 334 consecutive patients with anterior circulation infarction undergoing endovascular therapy were enrolled in our study. sICH was defined using Heidelberg bleeding classification after endovascular therapy. Multiple regression analysis was used to investigate the potential risk factors of sICH after endovascular therapy. We used receiver operating characteristic curve analysis and nomogram analysis to assess the overall discriminative ability of the HAR in predicting sICH after endovascular therapy.ResultsAmong these 334 patients enrolled, 37 (11.1%) patients with anterior circulation infarction were identified with sICH after endovascular therapy. Univariate logistic regression analysis demonstrated that patients with higher levels of HAR may be inclined to develop sICH (odds ratio, 10.994; 95% confidence interval, 4.567–26.463;P= 0.001). This association remained significant even after adjustment for potential confounders. Also, a cutoff value of 0.526× 10− 3for HAR was detected in predicting sICH (area under curve, 0.763). Furthermore, nomogram analysis also suggested that HAR was an indicator of sICH (c-index was 0.890,PConclusionsThis study showed that high levels of HAR could predict sICH after endovascular therapy. |
| اللغة: | English |
| تدمد: | 1471-2377 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1bbd6caf8e7c906455d7a7279c9a30dTest https://doaj.org/article/64423f31b16c43aab579bf6b477128cfTest |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d1bbd6caf8e7c906455d7a7279c9a30d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14712377 |
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