False-Positive Enzymatic Alcohol Results in Perimortem Specimens
| العنوان: | False-Positive Enzymatic Alcohol Results in Perimortem Specimens |
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| المؤلفون: | Sandra C Bishop-Freeman, Roger L Bertholf, Ruth E. Winecker, Robert H. Powers, Lisa C Mayhew |
| المصدر: | Laboratory Medicine. 51:394-401 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Chromatography, Gas, Clinical Biochemistry, Alcohol, 01 natural sciences, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Lactate dehydrogenase, Humans, False Positive Reactions, Lactic Acid, 030216 legal & forensic medicine, Child, Alcohol dehydrogenase, chemistry.chemical_classification, Chromatography, Ethanol, L-Lactate Dehydrogenase, biology, 010401 analytical chemistry, Biochemistry (medical), Alcohol Dehydrogenase, Forensic toxicology, Infant, 0104 chemical sciences, Lactic acid, Enzyme, chemistry, biology.protein, Gas chromatography, Blood Chemical Analysis |
| الوصف: | Herein, we present 2 cases referred to the North Carolina Office of the Chief Medical Examiner (NC OCME) in which ethanol results reported by different hospital laboratories, using alcohol dehydrogenase (ADH)–based assays, were positive, whereas results of headspace gas chromatography testing performed in the NC OCME laboratory were negative. Literature reports suggest that false-positive ethanol measurements from ADH-based assays can occur when a combination of elevated lactate and lactate dehydrogenase (LD) are present in the specimen. The results were reported in perimortem specimens collected from 2 children with unrelated medical conditions. The cases and associated clinical parameters are considered based on the lactate/LD explanation for the false-positive results, to facilitate the recognition of circumstances that can produce erroneous serum ethanol results. |
| تدمد: | 1943-7730 0007-5027 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d17ca456a494f14a981110a5394e7dc0Test https://doi.org/10.1093/labmed/lmz082Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d17ca456a494f14a981110a5394e7dc0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19437730 00075027 |
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