Current Updates on Potential Role of Flavonoids in Hypoxia/Reoxygenation Cardiac Injury Model
| العنوان: | Current Updates on Potential Role of Flavonoids in Hypoxia/Reoxygenation Cardiac Injury Model |
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| المؤلفون: | Wan Amir Nizam Wan Ahmad, Liza Noordin, Satirah Zainalabidin, Shafreena Shaukat Ali, Zakiah Jubri, Ruzilawati Abu Bakar |
| المصدر: | Cardiovascular Toxicology. 21:605-618 |
| بيانات النشر: | Springer Science and Business Media LLC, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cardiac function curve, Ischemic Heart Diseases, Anti-Inflammatory Agents, Apoptosis, Myocardial Reperfusion Injury, 030204 cardiovascular system & hematology, Experimental laboratory, Toxicology, Bioinformatics, Antioxidants, Mitochondria, Heart, 03 medical and health sciences, 0302 clinical medicine, Reperfusion therapy, medicine, Animals, Myocytes, Cardiac, Molecular Biology, Flavonoids, business.industry, Hypoxia (medical), Diet, Disease Models, Animal, Oxidative Stress, 030220 oncology & carcinogenesis, Injury model, Hypoxia reoxygenation, Inflammation Mediators, medicine.symptom, Cardiology and Cardiovascular Medicine, Cell culture model, business, Signal Transduction |
| الوصف: | Clinically, timely reperfusion strategies to re-establish oxygenated blood flow in ischemic heart diseases seem to salvage viable myocardium effectively. Despite the remarkable improvement in cardiac function, reperfusion therapy could paradoxically trigger hypoxic cellular injury and dysfunction. Experimental laboratory models have been developed over the years to explain better the pathophysiology of cardiac ischemia-reperfusion injury, including the in vitro hypoxia-reoxygenation cardiac injury model. Furthermore, the use of nutritional myocardial conditioning techniques have been successful. The cardioprotective potential of flavonoids have been greatly linked to its anti-oxidant, anti-apoptotic and anti-inflammatory properties. While several studies have reviewed the cardioprotective properties of flavonoids, there is a scarce evidence of their function in the hypoxia-reoxygenation injury cell culture model. Hence, the aim of this review was to lay out and summarize our current understanding of flavonoids' function in mitigating hypoxia-reoxygenation cardiac injury based on evidence from the last five years. We also discussed the possible mechanisms of flavonoids in modulating the cardioprotective effects as such information would provide invaluable insight on future therapeutic application of flavonoids. |
| تدمد: | 1559-0259 1530-7905 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d150636c6035fd4215ab0749534936caTest https://doi.org/10.1007/s12012-021-09666-xTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d150636c6035fd4215ab0749534936ca |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15590259 15307905 |
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