Phytochemicals containing biologically active polyphenols as an effective agent against Covid-19-inducing coronavirus
| العنوان: | Phytochemicals containing biologically active polyphenols as an effective agent against Covid-19-inducing coronavirus |
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| المؤلفون: | Katarzyna Mikula, Katarzyna Chojnacka, Dawid Skrzypczak, Piotr Młynarz, Anna Witek-Krowiak |
| المصدر: | Journal of Functional Foods Journal of Functional Foods, Vol 73, Iss, Pp 104146-(2020) |
| بيانات النشر: | Elsevier BV, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, GSH, Herbal extract from Gentianae Radix, 3CLpro, 3C-like protease, TCH, Herbal extract from Loranthi Ramus, FFA, Free fatty acid, IC50, 50% inhibitory concentrations, Covid-19, Coronavirus Disease 2019, Phytochemicals, CDC, Cholesterol-dependent cytolysin, Medicine (miscellaneous), Pharmacology, medicine.disease_cause, GCG, Gallocatechin gallate, Bioactivity, CTH, Herbal extract from Cassiae Semen, MNP, Marine Natural Product, chemistry.chemical_compound, DNA, Deoxyribonucleic acid, MERS-CoV, Middle East Respiratory Syndrome Coronavirus, Mpro, The major protease, Betulinic acid, TX341-641, DBM, Herbal extract from Dioscoreae Rhizoma, PLpro, The papain-like protease, Coronavirus, chemistry.chemical_classification, Nutrition and Dietetics, Chemistry, food and beverages, Biological activity, 04 agricultural and veterinary sciences, 040401 food science, EC50, 50% effective concentration, Pharmacophore, PLY, Pneumolysin, Article, WHO, World Health Organization, 03 medical and health sciences, 0404 agricultural biotechnology, SARS-CoV, Severe Acute Respiratory Syndrome coronavirus, ACE2, Angiotensin-converting enzyme 2, medicine, RNA, Ribonucleic acid, Antiviral, ComputingMethodologies_COMPUTERGRAPHICS, 030109 nutrition & dietetics, Pandemic, Nutrition. Foods and food supply, CBE, CBM, Herbal extracts from Rhizoma Cibotii, Polyphenols, Plant extracts, MTT test, Cytotoxicity test using 3- (4,5-dimethylthiazol-2-yl) −2,5-diphenyltetrazolium bromide, Enzyme, CC50, 50% cytotoxicity concentration, Viral replication, Polyphenol, FA, Fatty acid, Luteolin, CPE, Cytopathogenic effect, Food Science |
| الوصف: | Graphical abstract Highlights • Plant extracts are a source of phytochemicals useful in the treatment of coronavirus diseases. • The advantage of using natural plant extracts is their effectiveness and high safety for patients. • Water and ethanol plant extracts contain biologically active substances with antiviral activity. • Phytochemicals are natural inhibitors of viral enzymes. The outbreak of Covid-19 disease caused by SARS-CoV-19, along with the lack of targeted medicaments and vaccines, forced the scientific world to search for new antiviral formulations. In this review, we describe the current knowledge about plant extracts containing polyphenols that inhibit Covid-19. Many plant-derived natural compounds (polyphenols) might provide a starting point for the research on the use of plant extracts in coronavirus treatment and prevention. Antivirus polyphenolic drugs can inhibit coronavirus enzymes, which are essential for virus replication and infection. This group of natural substances (betulinic acid, indigo, aloeemodine, luteolin, and quinomethyl triterpenoids, quercitin or gallates) is a potential key to designing antiviral therapies for inhibiting viral proteases. The known pharmacophore structures of bioactive substances can be useful in the elaboration of new anti-Covid-19 formulations. The benefit of using preparations containing phytochemicals is their high safety for patients and no side effects. |
| اللغة: | English |
| تدمد: | 1756-4646 |
| DOI: | 10.1016/j.jff.2020.104146 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d14cee82201483e806e223697fbea2f9Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d14cee82201483e806e223697fbea2f9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 17564646 |
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| DOI: | 10.1016/j.jff.2020.104146 |