Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer
| العنوان: | Promoter methylation analysis of WNT/β-catenin pathway regulators and its association with expression of DNMT1 enzyme in colorectal cancer |
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| المؤلفون: | Yaghoub Yazdani, Touraj Farazmandfar, Nader Mansour Samaei, Hossein Azadeh, Reza Alizadeh-Navaei |
| المصدر: | Journal of Biomedical Science |
| بيانات النشر: | BioMed Central, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, DNA (Cytosine-5-)-Methyltransferase 1, Male, Beta-catenin, Endocrinology, Diabetes and Metabolism, Clinical Biochemistry, WIF1, Gene Expression Regulation, Enzymologic, Sex Factors, Humans, Pharmacology (medical), DNA (Cytosine-5-)-Methyltransferases, Promoter Regions, Genetic, Molecular Biology, Wnt Signaling Pathway, beta Catenin, Aged, Regulation of gene expression, Biochemistry, medical, biology, Research, Biochemistry (medical), DNMT1, Wnt signaling pathway, Age Factors, WNT/β-catenin signaling, General Medicine, Methylation, Cell Biology, DNA, Neoplasm, DNA Methylation, Middle Aged, Promoter methylation, Molecular biology, Colorectal cancer, Neoplasm Proteins, Gene Expression Regulation, Neoplastic, Catenin, DNA methylation, Cancer research, biology.protein, Female, Colorectal Neoplasms |
| الوصف: | Background Aberrant DNA methylation as the most important reason making epigenetic silencing of genes is a main mechanism of gene inactivation in patients with colorectal cancer. In this study, we decided to identify promoter methylation status of ten genes encoding WNT negative regulators, and measure the expression of DNMT1 enzyme in colorectal cancer samples. Results Aberrant methylation of APC gene was statistically significant associated with age over 50 (p = 0.017), DDK3 with male (p |
| اللغة: | English |
| تدمد: | 1423-0127 1021-7770 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d103203c1a29934ab07d7df3991effcbTest http://europepmc.org/articles/PMC4237828Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d103203c1a29934ab07d7df3991effcb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230127 10217770 |
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