Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population
| العنوان: | Amerind ancestry, socioeconomic status and the genetics of type 2 diabetes in a Colombian population |
|---|---|
| المؤلفون: | Tábita Hünemeier, Liliana Franco, Andres Ruiz-Linares, Mark I. McCarthy, Cátira Bortolini, Natalia Gallego, Constanza Duque, Alberto Villegas, Desmond Campbell, Alkes L. Price, David Reich, María Victoria Parra, Gabriel Bedoya, Arti Tandon |
| المصدر: | PLoS ONE Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS PLoS ONE, Vol 7, Iss 4, p e33570 (2012) |
| بيانات النشر: | Public Library of Science, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | Candidate gene, endocrine system diseases, Non-Clinical Medicine, lcsh:Medicine, Population genetics, Genome-wide association study, Genética humana, Global Health, Body Mass Index, 0302 clinical medicine, Endocrinology, Gene Frequency, lcsh:Science, Genetics, 0303 health sciences, Multidisciplinary, Socioeconomic Aspects of Health, Diabetes mellitus tipo 2, Medicine, Research Article, Gene Flow, Ameríndios, Genetic admixture, 030209 endocrinology & metabolism, Ancestry-informative marker, Biology, Colombia, Polymorphism, Single Nucleotide, 03 medical and health sciences, Genome-Wide Association Studies, Humans, Genetic Predisposition to Disease, Allele, Allele frequency, Alleles, 030304 developmental biology, Genetic association, Diabetic Endocrinology, Indians, South American, lcsh:R, Human Genetics, Diabetes Mellitus Type 2, Diabetes Mellitus, Type 2, Social Class, Genetic Loci, Case-Control Studies, Genetics of Disease, lcsh:Q, Lod Score, Population Genetics, Genome-Wide Association Study |
| الوصف: | The “thrifty genotype” hypothesis proposes that the high prevalence of type 2 diabetes (T2D) in Native Americans and admixed Latin Americans has a genetic basis and reflects an evolutionary adaptation to a past low calorie/high exercise lifestyle. However, identification of the gene variants underpinning this hypothesis remains elusive. Here we assessed the role of Native American ancestry, socioeconomic status (SES) and 21 candidate gene loci in susceptibility to T2D in a sample of 876 T2D cases and 399 controls from Antioquia (Colombia). Although mean Native American ancestry is significantly higher in T2D cases than in controls (32% v 29%), this difference is confounded by the correlation of ancestry with SES, which is a stronger predictor of disease status. Nominally significant association (P1 was observed for markers selected from previous T2D genome-wide association studies, consistent with a role for Old World variants in susceptibility to T2D in Latin Americans. No association was found to the only known Native American-specific gene variant previously associated with T2D in a Mexican sample (rs9282541 in ABCA1). An admixture mapping scan with 1,536 ancestry informative markers (AIMs) did not identify genome regions with significant deviation of ancestry in Antioquia. Exclusion analysis indicates that this scan rules out ∼95% of the genome as harboring loci with ancestry risk ratios >1.22 (at P < 0.05). |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1932-6203 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0b727c5273df3f69fbc66932852bc0dTest https://doi.org/10.1371/journal.pone.0033570Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....d0b727c5273df3f69fbc66932852bc0d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
|---|