Peptide-Based Nanoparticles Mimic Fibrillogenesis of Laminin in Tumor Vessels for Precise Embolization
| العنوان: | Peptide-Based Nanoparticles Mimic Fibrillogenesis of Laminin in Tumor Vessels for Precise Embolization |
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| المؤلفون: | Ping-Ping He, Zi-Ming Chen, Kai Yue, Zhou Yang, Xiao-Ran Zou, Hua Zhang, Xinxin Zhang, Pei-Pei Yang, Lei Wang, Shi-Fang Wen, Yu Fan, Kuo Zhang, Hui Cao, Hao Wang |
| المصدر: | ACS Nano. 14:7170-7180 |
| بيانات النشر: | American Chemical Society (ACS), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Angiogenesis, medicine.medical_treatment, General Physics and Astronomy, Tumor cells, Peptide, 02 engineering and technology, 010402 general chemistry, 01 natural sciences, chemistry.chemical_compound, Laminin, Neoplasms, Tumor Microenvironment, medicine, Humans, General Materials Science, Embolization, chemistry.chemical_classification, Neovascularization, Pathologic, biology, General Engineering, Cancer, Fibrillogenesis, 021001 nanoscience & nanotechnology, medicine.disease, 0104 chemical sciences, chemistry, Cancer research, biology.protein, Nanoparticles, Growth inhibition, Peptides, 0210 nano-technology |
| الوصف: | Cancer therapeutic strategies based on angiogenesis attract great attention from fundamental and clinical research. Blocking oxygen and nutrition supply to tumor cells could inhibit the growth of tumors based on occlusion of blood vessels in the tumor. Herein, we report a dual-responsive peptide-based nanoparticle, mimicking the laminin fibrillogenesis specifically and highly efficiently in tumor vessels, resulting in the blockage of tumor vessels and the growth inhibition of tumors. The laminin mimic peptide (LMMP) is designed with a fibrillation sequence, a pH-responsive sequence, and a targeting sequence. The LMMP in nanoformulations is delivered to blood vessels in the tumors, where the microenvironment (pH and microthrombus) enable LMMP to process laminin fibrillogenesis, constructing fibrous networks. The laminin-like fibrous networks capture red blood cells etc., forming occlusion specifically in the tumor blood vessels to inhibit the growth of the tumor. |
| تدمد: | 1936-086X 1936-0851 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d078fe2d54ae772eb12fcb4e05e84934Test https://doi.org/10.1021/acsnano.0c02110Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....d078fe2d54ae772eb12fcb4e05e84934 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1936086X 19360851 |
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